{
  "abstract": "In membranous nephropathy (MN), an autoimmune kidney condition, univariate genome-wide association studies (GWAS) have identified Human Leucocyte Antigen ( HLA ) and M-type phospholipase A2 receptor ( PLA2R1 ) genetic risk variants. Multivariate-single nucleotide polymorphism (SNP) canonical correlation analysis (CCA) with transcriptomics analysis, can uncover additional insights within this context. We applied CCA to our National Unified Renal Translational Research Enterprise (NURTuRE)- chronic kidney disease (CKD) and Salford Kidney Study (SKS) European datasets, identifying 1095 HLA and 46 PLA2R1 SNPs showing significant MN correlation, and single-cell gene enrichment. Top SNP combinations showed greater significance in both MN by multivariate-SNP CCA, and MN and diabetic nephropathy (Type 1) by allele frequency analysis compared to healthy and non-MN groups. ATF6B , C2, CYP21A2 , and HLA-DRB1 colocalised with top HLA SNPs and showed significant differential expression in MN (published immune transcriptomics datasets). HLA-DQB1, HLA-DRB5 and RNF5 showed significant differential expression with lead SNP genotype status in MN and CKD. These previously unreported SNP and gene results are candidates for MN and potentially Type 1 diabetic nephropathy risk prediction.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Amy J. Osborne",
      "orcid": "0000-0001-6869-1176"
    },
    {
      "name": "Samantha Hayward"
    },
    {
      "name": "Elizabeth Colby"
    },
    {
      "name": "Uwe Andag"
    },
    {
      "name": "Philip A. Kalra"
    },
    {
      "name": "Ania Koziell",
      "orcid": "0000-0003-4882-0246"
    },
    {
      "name": "Olivier Radresa"
    },
    {
      "name": "Philipp Skroblin"
    },
    {
      "name": "Maarten W. Taal",
      "orcid": "0000-0002-9065-212X"
    },
    {
      "name": "Gavin I. Welsh",
      "orcid": "0000-0002-2148-6658"
    },
    {
      "name": "Moin A. Saleem",
      "orcid": "0000-0002-9808-4518"
    },
    {
      "name": "Colin Campbell",
      "orcid": "0000-0002-4775-9802"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5se2vy6ptz9q1.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11211-x",
  "fulltext_url": null,
  "id": "5se2vy6ptz9q1",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11211-x",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/5se2vy6ptz9q1.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:21:36Z",
      "native_id": "10.1038/s42003-026-11211-x",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11211-x"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2399-3642",
      "subfield": "general"
    }
  ],
  "title": "Canonical correlation analysis identifies single nucleotide polymorphism combinations and gene expression associated with membranous nephropathy",
  "title_text": "Canonical correlation analysis identifies single nucleotide polymorphism combinations and gene expression associated with membranous nephropathy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T00:20:37Z",
  "url": "https://research.draconitic.com/paper/5se2vy6ptz9q1",
  "venue": "Communications Biology",
  "versions": []
}