{
  "abstract": "A 69-year-old man with acute promyelocytic leukemia in molecular remission and no detectable PML::RARA transcripts in his peripheral blood cells developed acute otitis media. After 10 months, tympanomastoidectomy was performed for suspected secondary cholesteatoma. A histological examination confirmed extramedullary relapse with PML::RARA-positive cell infiltration. The patient achieved a second molecular remission after treatment with arsenic trioxide. Our findings suggest that (1) a diagnostic sample may be obtained from mastoid air cells rather than from the middle ear cavity, (2) molecular remission does not preclude extramedullary relapse, and (3) all-trans retinoic acid and arsenic trioxide combination therapy may reduce the risk of extramedullary relapse.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Noriko Tsuge"
    },
    {
      "name": "Taisuke Kobayashi"
    },
    {
      "name": "Masahiro Komori"
    },
    {
      "name": "Ichiro Murakami"
    },
    {
      "name": "Tatsuya Negishi"
    },
    {
      "name": "Shohei Shigeto"
    },
    {
      "name": "Yuta Tsunaga"
    },
    {
      "name": "Keito Ohara"
    },
    {
      "name": "Shinichiro Watanabe"
    },
    {
      "name": "Shohei Yoshida"
    },
    {
      "name": "Kensuke Kojima"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5skvgs1p8jdrv.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.8006-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8006-26/_article",
  "id": "5skvgs1p8jdrv",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8006-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "1312|Retinoids in leukemia and cellular processes"
    ]
  ],
  "openalex": "W7214607331",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8006-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5skvgs1p8jdrv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.8006-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8006-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Retinoids in leukemia and cellular processes",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Extramedullary Relapse of Acute Promyelocytic Leukemia in the Middle Ear after All-Trans Retinoic Acid Combined with Chemotherapy",
  "title_text": "Extramedullary Relapse of Acute Promyelocytic Leukemia in the Middle Ear after All-Trans Retinoic Acid Combined with Chemotherapy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/5skvgs1p8jdrv",
  "venue": "Internal Medicine",
  "versions": []
}