{
  "abstract": "Autoantibodies (auto-Abs) neutralizing type I interferons (IFN-I) underlie various life-threatening viral infections, and the prevalence of these auto-Abs rises sharply between 65 and 70 years of age. We investigated the familial aggregation of neutralizing IFN-I auto-Abs by assessing concordance rates in Danish older twins, including 3,270 twins aged 65-96 years in a sample comprising 1,318 intact twin pairs (2,636 individuals) and 634 twins from broken twin pairs (634 individuals). Neutralizing IFN-I auto-Abs were detected in 1.5% (50/3,270) of all twins tested, including 1.4% (37/2,636) in twins from intact pairs and 2.1% (13/634) in twins from broken pairs. A total of 50 twins had neutralizing IFN-I auto-Abs, including one concordant monozygotic pair and 35 discordant pairs, yielding a low overall concordance rate. A slight, but nonsignificant, increase in mortality was associated with harboring neutralizing IFN-I auto-Abs. Collectively, these findings do not reveal any familial aggregation of IFN-I auto-Abs, arguing against a strong germline genetic etiology of IFN-I auto-Abs in older adults.",
  "abstract_shown": true,
  "affiliations": [
    "Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.",
    "The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.",
    "Department of Biomedicine, Aarhus University, Aarhus, Denmark.",
    "Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.",
    "Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.",
    "Imagine Institute, Paris Cité University , Paris, France.",
    "Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France.",
    "Laboratory of Human Genetics of Infectious Diseases, Center for the Genetics of Host Defense, University of Texas Southwestern, Dallas, TX, USA.",
    "Departments of Pediatrics and Immunology, and Children Research Institute, University of Texas Southwestern, Dallas, TX, USA.",
    "Howard Hughes Medical Institute , New York, NY, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Signe Bedsted Clemmensen",
      "orcid": "0000-0001-9871-149X"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Nanna Mørk",
      "orcid": "0009-0003-9848-3425"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Julie A Jensen",
      "orcid": "0009-0002-9704-5442"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Lisbeth Aagaard Larsen",
      "orcid": "0000-0002-0426-0569"
    },
    {
      "affs": [
        2
      ],
      "name": "Bettina Bundgaard",
      "orcid": "0009-0004-6979-4256"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Marianne Nygaard",
      "orcid": "0000-0003-0703-2665"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Michelle Møhlenberg",
      "orcid": "0000-0002-3769-4902"
    },
    {
      "affs": [
        2
      ],
      "name": "Morten K Skouboe",
      "orcid": "0000-0001-9358-5500"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Adrian Gervais",
      "orcid": "0000-0002-1083-5787"
    },
    {
      "affs": [
        4,
        5,
        6
      ],
      "name": "Paul Bastard",
      "orcid": "0000-0002-5926-8437"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Anne Puel",
      "orcid": "0000-0003-2603-0323"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Aurelie Cobat",
      "orcid": "0000-0001-7209-6257"
    },
    {
      "affs": [
        4,
        5,
        7,
        8,
        9
      ],
      "name": "Jean-Laurent Casanova",
      "orcid": "0000-0002-7782-4169"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kaare Christensen",
      "orcid": "0000-0002-5429-5292"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Trine H Mogensen",
      "orcid": "0000-0002-1853-9704"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5snea79n305qx.bib",
  "cited_by": 0,
  "doi": "10.70962/jhi.20260142",
  "fulltext_url": "https://europepmc.org/articles/PMC13651747",
  "id": "5snea79n305qx",
  "issns": [
    "3065-8993"
  ],
  "landing_url": "https://europepmc.org/article/MED/42853147",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|interferon and immune responses"
    ]
  ],
  "openalex": "W7221128107",
  "pdf_url": "https://europepmc.org/articles/PMC13651747?pdf=render",
  "pmcid": "PMC13651747",
  "pmid": "42853147",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5snea79n305qx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "MED:42853147",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42853147"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|interferon and immune responses",
      "subfield": "immunology"
    }
  ],
  "title": "Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance.",
  "title_text": "Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/5snea79n305qx",
  "venue": "Journal of human immunity",
  "versions": []
}