{
  "abstract": "Predicting lung cancer risk would enhance prevention trials. Although the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial demonstrated reduced lung cancer incidence with interleukin (IL)-1β inhibition, the high number needed to treat (NNT) to prevent lung cancer limits its use in unselected populations. Using machine learning, we identified a 14-protein plasma signature predicting lung cancer more than 5 years before diagnosis. The signature, validated across eight cohorts, was elevated in current smokers and individuals exposed to particulate matter (PM) and linked to lung myeloid and alveolar cells. In epidermal growth factor receptor ( EGFR )-driven lung adenocarcinoma, diverse epithelial lineages converged on a keratin8 + /claudin4 + alveolar transitional state (KAC), whose transcriptional programs correlated with signature emergence. Components of the signature were induced by PM, oncogenic EGFR , or IL-1β, whereas IL-1β inhibition restrained PM-driven KAC expansion and early tumorigenesis. In CANTOS, the signature identified individuals who seemed to benefit more from anti-IL-1β therapy, lowering the NNT threshold and nominating circulating signals of tumor promotion for prevention.",
  "abstract_shown": true,
  "affiliations": [
    "Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK; UKRI UCL Centre for Doctoral Training in AI-enabled Healthcare Systems, University College London, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK",
    "Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK",
    "Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; Cancer Genome Evolution Research Group, University College London Cancer Institute, London, UK",
    "Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; Division of Medicine, University College London, London, UK",
    "Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK",
    "Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia",
    "Department of Cell Biology, Albert Einstein College of Medicine, Montefiore Health System, Bronx, New York, NY, USA; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA",
    "Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London, UK; Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia",
    "Immunoregulation Laboratory, The Francis Crick Institute, London, UK",
    "Autoimmunity Laboratory, The Francis Crick Institute, London, UK",
    "Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; Cancer Metastasis Laboratory, University College London Cancer Institute, London, UK",
    "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK",
    "Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK; Oxford Global Health, University of Oxford, Oxford, UK",
    "Novartis, Cambridge, MA, USA",
    "Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA",
    "Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK",
    "Tumour Cell Biology Laboratory, The Francis Crick Institute, London, UK",
    "Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London, UK",
    "Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; Genomics Science Technology Platform, The Francis Crick Institute, London, UK",
    "Genomics Science Technology Platform, The Francis Crick Institute, London, UK",
    "Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA",
    "Imaging Research Facility, The Francis Crick Institute, London, UK",
    "Department of Pathobiology & Population Sciences, The Royal Veterinary College, London, UK; Experimental Histopathology, The Francis Crick Institute, London, UK",
    "Department of Pathobiology & Population Sciences, The Royal Veterinary College, London, UK",
    "Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA",
    "Early Detection, Prevention and Infections Branch (EPR), International Agency for Research on Cancer (IARC/WHO), Lyon, France",
    "Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA",
    "Department of Population Health Sciences, British Columbia Cancer Research Institute, Vancouver, BC, Canada",
    "Department of Basic and Translational Research, British Columbia Cancer Research Institute, Vancouver, BC, Canada",
    "Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK; Department of Thoracic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan",
    "Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands",
    "Novartis Biomedical Research, Cambridge, MA, USA",
    "Novartis Pharmaceuticals, Basel, Switzerland",
    "Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, UK",
    "UCL Innovative Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK",
    "Department of Mathematics and Institute for Women's Health, University College London, London, UK; Centre for Cognition and Decision making, Institute for Cognitive Neuroscience, HSE University, Moscow, Russia",
    "Department of Women's Cancer, Institute for Women's Health, University College London, London, UK",
    "National Phenome Centre and Imperial Clinical Phenotyping Centre, Department of Metabolism, Digestion and Reproduction, IRDB, Imperial College London, London, UK; Section of Bioanalytical Chemistry, Burlington Danes Building, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK",
    "Nuffield Department of Population Health, University of Oxford, Oxford, UK",
    "Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London, UK; Department of Women's Cancer, Institute for Women's Health, University College London, London, UK"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 87,
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      "name": "Tej Pandya",
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      "name": "Maria Zagorulya",
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      "name": "Michelle M. Leung",
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      "name": "Marcellus Augustine",
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      "name": "Lydia Liu",
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      "name": "Aino‐Maija Leppä",
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      "name": "K Chan"
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      "name": "Jincheng Wu"
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      "name": "Vernon A. Burk",
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      "name": "Alix Le Marois",
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      "name": "Ekaterina Pazukhina",
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      "name": "Sophia Ward",
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      "name": "Hubert Slawinski",
      "orcid": "0000-0002-8996-8477"
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      "name": "Marc R. Pelletier",
      "orcid": "0000-0003-2860-591X"
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        4
      ],
      "name": "Cian Murphy",
      "orcid": "0000-0003-1356-959X"
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      "name": "Matthew D. Park",
      "orcid": "0000-0003-3488-3262"
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      ],
      "name": "Thomas J. A. Snoeks",
      "orcid": "0000-0003-3866-346X"
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      ],
      "name": "Alejandro Suárez‐Bonnet",
      "orcid": "0000-0003-0296-5896"
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      ],
      "name": "Simon Lawrence Priestnall",
      "orcid": "0000-0002-6027-1879"
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      ],
      "name": "Alexandros Hardas",
      "orcid": "0000-0001-9906-7552"
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      "name": "Charlotte Grieco",
      "orcid": "0000-0003-3177-7245"
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      "name": "Ami Archer"
    },
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        1
      ],
      "name": "Alpkaan Celik"
    },
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      ],
      "name": "Alejandro Jiménez-Sánchez",
      "orcid": "0000-0003-1879-7057"
    },
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        10
      ],
      "name": "Rachel Scott",
      "orcid": "0009-0002-8442-7118"
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      ],
      "name": "Hana Zahed",
      "orcid": "0000-0002-5731-8859"
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      "affs": [
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      ],
      "name": "Léa Montégut",
      "orcid": "0000-0003-4778-4757"
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      ],
      "name": "Rafael Meza",
      "orcid": "0000-0002-1076-5037"
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      ],
      "name": "Clinton H. Durney",
      "orcid": "0000-0002-2385-1620"
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      "name": "Stephen C. Lam",
      "orcid": "0000-0002-3964-1492"
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      "name": "Takahiro Karasaki",
      "orcid": "0000-0001-6863-2360"
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      "name": "Roel C.H. Vermeulen",
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      "name": "Huilei Xu",
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      ],
      "name": "Pablo Serrano‐Fernández",
      "orcid": "0000-0003-2886-5391"
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      ],
      "name": "Tatjana Crnogorac‐Jurcevic",
      "orcid": "0000-0002-2465-5605"
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        34
      ],
      "name": "Usha Menon",
      "orcid": "0000-0003-3708-1732"
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      ],
      "name": "Sophia Apostolidou",
      "orcid": "0000-0003-2659-0451"
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      "affs": [
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      ],
      "name": "Alexey A. Zaikin",
      "orcid": "0000-0001-7540-1130"
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      "name": "Richard Gunu",
      "orcid": "0000-0002-8745-4915"
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      "name": "Harry J. Whitwell",
      "orcid": "0000-0001-8987-4158"
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      "name": "Zhe Huang"
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      ],
      "name": "Zonglun Li",
      "orcid": "0000-0002-4722-615X"
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    {
      "name": "Xin Hu",
      "orcid": "0000-0002-7403-8808"
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    {
      "name": "Bo Zhu",
      "orcid": "0000-0003-2439-0026"
    },
    {
      "name": "Liming Li"
    },
    {
      "name": "MD Chirlaque"
    },
    {
      "name": "Marcela Guevara",
      "orcid": "0000-0001-9242-6364"
    },
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      "affs": [
        30
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      "name": "Pieter Martijn Kolijn",
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      "name": "Aghiles Guenoun",
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  ],
  "bibtex": "https://research.draconitic.com/paper/5sqb97cynvnm7.bib",
  "cited_by": 22,
  "doi": "10.1016/j.cell.2026.05.005",
  "fulltext_url": null,
  "id": "5sqb97cynvnm7",
  "issns": [
    "0092-8674",
    "1097-4172"
  ],
  "landing_url": "https://doi.org/10.1016/j.cell.2026.05.005",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "openalex",
      "2730|Lung Cancer Research Studies"
    ]
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  "openalex": "W7163591960",
  "pdf_url": null,
  "pmcid": "PMC13573819",
  "pmid": "42242224",
  "published": "2026-06-01",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/5sqb97cynvnm7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:54Z",
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      "source": "openalex",
      "url": "https://doi.org/10.1016/j.cell.2026.05.005"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Lung Cancer Research Studies",
      "subfield": "oncology"
    }
  ],
  "title": "Plasma signals of lung tumor promotion for molecular cancer prevention",
  "title_text": "Plasma signals of lung tumor promotion for molecular cancer prevention",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:50Z",
  "url": "https://research.draconitic.com/paper/5sqb97cynvnm7",
  "venue": "Cell",
  "versions": []
}