{
  "abstract": "Background/Objectives: Serial laboratory measurements may capture within-episode changes not represented by a single baseline value, while routine markers from different biological domains may not evolve concordantly. Methods: We retrospectively analyzed 100 hospital admission episodes in which the source infection field explicitly recorded sepsis. A complete source-record re-audit confirmed sepsis wording in all 100 episodes and identified no severe-infection-only subgroup. Because complete SOFA components were unavailable, Sepsis-3 criteria were not retrospectively adjudicated. Procalcitonin (PCT), C-reactive protein (CRP), white blood cell count (WBC), platelet count, and serum creatinine were evaluated across three ordered recorded assessment points using random-intercept linear mixed-effects models, with Holm correction across five primary global tests and generalized estimating equations as robustness analyses. Results: PCT geometric means decreased from 0.925 to 0.306 ng/mL (Holm-adjusted p = 0.000052), CRP from 104.2 to 36.0 mg/L (p < 0.001), and serum creatinine from 1.49 to 1.10 mg/dL (p = 0.000074). Platelet count increased on the additive scale (p = 0.000237) but not after logarithmic transformation, whereas the full-cohort primary WBC model was non-significant (p = 0.0743). Conclusions: Routine laboratory markers showed heterogeneous cohort-level longitudinal patterns, supporting marker-specific rather than uniform interpretation of serial measurements.",
  "abstract_shown": true,
  "affiliations": [
    "Doctoral School, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania",
    "Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timișoara, Romania",
    "Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, Victor Babeș University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania",
    "Dr. Victor Babeș Clinical Hospital of Infectious Diseases and Pneumophthisiology, 300310 Timișoara, Romania",
    "Department XIII, Discipline of Infectious Diseases, Victor Babeș University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania",
    "Discipline of Neonatology, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania",
    "Department of Pediatric Surgery and Orthopedics, Victor Babeș University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania",
    "Department XII, Discipline of Obstetrics and Gynecology, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Andra Rotea"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Bogdan Rotea",
      "orcid": "0009-0009-3398-9090"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Mădălina Suba",
      "orcid": "0009-0008-8387-7700"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Ovidiu Roșca",
      "orcid": "0000-0001-8236-2205"
    },
    {
      "affs": [
        0,
        1,
        5
      ],
      "name": "Bogdan Cerbu"
    },
    {
      "affs": [
        1,
        5
      ],
      "name": "Ileana Enătescu"
    },
    {
      "affs": [
        1,
        5
      ],
      "name": "Mirabela Dima"
    },
    {
      "affs": [
        1,
        6
      ],
      "name": "Emil Radu Iacob",
      "orcid": "0000-0002-5863-6613"
    },
    {
      "affs": [
        7
      ],
      "name": "Adrian Gluhovschi",
      "orcid": "0000-0001-8354-9928"
    },
    {
      "affs": [
        1,
        5
      ],
      "name": "Daniela Iacob",
      "orcid": "0000-0003-2468-6003"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5ssy2ffpegwgv.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218246",
  "fulltext_url": null,
  "id": "5ssy2ffpegwgv",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8246",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7223306667",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/5ssy2ffpegwgv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15218246",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8246"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Sepsis Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Serial Changes in Routine Inflammatory, Hematologic, and Renal Laboratory Markers in Adults Hospitalized with Clinically Recorded Sepsis: A Longitudinal Observational Cohort Study",
  "title_text": "Serial Changes in Routine Inflammatory, Hematologic, and Renal Laboratory Markers in Adults Hospitalized with Clinically Recorded Sepsis: A Longitudinal Observational Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:01Z",
  "url": "https://research.draconitic.com/paper/5ssy2ffpegwgv",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}