{
  "abstract": "This study investigated the recovery and nanoliposomal formulation of anthocyanin-rich extracts from black rice using choline chloride-based deep eutectic solvents (DESs). Choline chloride/1,2-propanediol (DES2) produced the highest anthocyanin content, 85.5 ± 3.4 mg l−1, after optimization, compared with 25.7 ± 2.1 mg l−1 obtained by conventional ethanol extraction. High-resolution QTOF-MS/MS enabled the tentative assignment of cyanidin 3-O-hexoside-type and peonidin 3-O-hexoside-type compounds based on accurate precursor masses and characteristic product ions; authentic-standard confirmation was not performed. The DES2 extract showed greater apparent thermal stability than the control extract, with estimated half-lives of 30.0 and 16.0 days, respectively, at 45°C. Anti-oxidant activity was observed in DPPH and ABTS assays, with IC50 values of 0.19 ± 0.06 and 0.16 ± 0.08 mg ml−1, respectively. Preliminary antibacterial activity against Escherichia coli was detected under the tested agar-diffusion conditions, whereas activity against Staphylococcus aureus was limited. Nanoliposomal encapsulation achieved an encapsulation efficiency of 73.8 ± 4.3%, a Z-average diameter of 201.3 nm and 89.83 ± 0.65% anthocyanin retention after 28 days at 4°C. The formulation produced a larger inhibition zone against E. coli than the free extract under the assay conditions. These findings support further investigation, although release kinetics, pharmaceutical efficacy and complete-process sustainability remain unestablished.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City 1 , Ho Chi Minh City, Vietnam",
    "Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City 2 , Ho Chi Minh City, Vietnam",
    "Faculty of Food Technology, Saigon Technology University 3 , Ho Chi Minh City, Vietnam",
    "Institute of Advanced Technology, Vietnam Academy of Science and Technology 4 , Ho Chi Minh City, Vietnam"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Quang-Hieu Tran",
      "orcid": "0000-0003-0644-1002"
    },
    {
      "affs": [
        1
      ],
      "name": "Ba Thanh Nguyen"
    },
    {
      "affs": [
        2
      ],
      "name": "Dat Pham Quoc"
    },
    {
      "affs": [
        2
      ],
      "name": "Nguyen Quynh Dao"
    },
    {
      "affs": [
        2
      ],
      "name": "Nguyen Thi Ngoc Tram"
    },
    {
      "affs": [
        3
      ],
      "name": "Nguyen Thanh Danh"
    },
    {
      "affs": [
        0
      ],
      "name": "Nguyen Quoc Thang"
    },
    {
      "affs": [
        0
      ],
      "name": "Le Van Tan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5stkj84z45680.bib",
  "cited_by": 1,
  "doi": "10.1098/rsos.260927",
  "fulltext_url": "https://europepmc.org/articles/PMC13682423",
  "id": "5stkj84z45680",
  "issns": [
    "2054-5703"
  ],
  "landing_url": "https://royalsocietypublishing.org/rsos/article/13/10/260927/483581/Choline-chloride-based-deep-eutectic-solvents-for",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1503|Ionic liquids properties and applications"
    ]
  ],
  "openalex": "W7221669588",
  "pdf_url": "https://royalsocietypublishing.org/rsos/article-pdf/doi/10.1098/rsos.260927/6169726/rsos.260927.pdf",
  "pmcid": "PMC13682423",
  "pmid": "42904199",
  "published": "2026-10-14",
  "publisher": "The Royal Society",
  "ris": "https://research.draconitic.com/paper/5stkj84z45680.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:45Z",
      "native_id": "10.1098/rsos.260927",
      "source": "crossref",
      "url": "https://royalsocietypublishing.org/rsos/article/13/10/260927/483581/Choline-chloride-based-deep-eutectic-solvents-for"
    },
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42904199",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42904199"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1503|Ionic liquids properties and applications",
      "subfield": "catalysis"
    }
  ],
  "title": "Choline chloride-based deep eutectic solvents for efficient anthocyanin recovery from black rice: process, kinetics and nanoliposomal formulation",
  "title_text": "Choline chloride-based deep eutectic solvents for efficient anthocyanin recovery from black rice: process, kinetics and nanoliposomal formulation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/5stkj84z45680",
  "venue": "Royal Society Open Science",
  "versions": []
}