{
  "abstract": "Background:\n\nHelicobacter pylori ( H. pylori ) infection causes gastritis, peptic ulcer disease, and gastric cancer. Without an effective vaccine, eradication therapy remains crucial. However, increasing antibiotic resistance compromises treatment effectiveness.\n\nObjective: To evaluate whether literature‐based resistance data could predict first‐line empirical treatment effectiveness.\n\nMethods: Resistance rates for clarithromycin, metronidazole, and levofloxacin were extracted from bibliographic reviews and estimated for three timeframes: the treatment year, the preceding year, and the last five years average. These rates (2008–2024) were matched with outcomes from the European Registry on H. pylori Management (Hp‐EuReg, WorldHpReg partner), a prospective real‐world study involving 40 countries. Analyses included Spearman's correlations, multivariate logistic regressions adjusted for demographic, clinical, and therapeutic‐related variables, bootstrap resampling stratified by eradication success, and Random Forest models.\n\nResults: Analysis included 37,659 patients receiving first‐line empirical treatment from 13 countries. Moderate negative correlations were observed between metronidazole and clarithromycin resistances for some regimens. In the regression model, including either contemporaneous or previous‐year resistance rates, clarithromycin resistance showed a negligible positive association, while metronidazole resistance was negatively associated. In regimen‐specific models, previous‐year clarithromycin resistance was positively associated with success in concomitant therapy, whereas higher five‐year mean clarithromycin resistance reduced eradication odds in quadruple clarithromycin–amoxicillin–bismuth therapy. Random Forest models identified compliance, proton‐pump inhibitor dose, regimen duration, and treatment as the strongest predictors of eradication, while resistance variables contributed minimally.\n\nConclusion: Literature‐based resistance data are not useful for guiding real‐world first‐line H. pylori therapy, highlighting the need for individualized antibiotic susceptibility testing to obtain reliable resistance information.\n\nTrial Registration: ClinicalTrials.gov identifier: NCT02328131",
  "abstract_shown": true,
  "affiliations": [
    "Methodology Unit, Instituto de Investigación Sanitaria Princesa (IIS‐Princesa), Rheumatology Service Hospital Universitario de La Princesa Madrid Spain",
    "Centro de Biotecnología y Genómica de Plantas UPM‐INIA/CSIC (CBGP) Universidad Politécnica de Madrid Madrid Spain",
    "Department of Gastroenterology Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS‐Princesa), Universidad Autónoma de Madrid (UAM), and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) Madrid Spain",
    "Department of Gastroenterology Hospital Universitario Costa del Sol, RICAPPS–Red de Investigación en Cronicidad, Atención Primaria y Prevención y Promoción de la Salud Marbella Spain",
    "Department of Gastroenterology DC Rogaska Rogaska Slatina Slovenia",
    "A.S. Loginov Moscow Clinical Scientific Center Moscow Russia",
    "Department of Gastroenterology Hospital Clínico Universitario Lozano Blesa, Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) Zaragoza Spain",
    "Department of Gastroenterology Hospital General de Tomelloso, Instituto de Investigación Sanitaria Princesa (IIS‐Princesa), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Investigación Sanitaria de Castilla‐La Mancha (IDISCAM) Tomelloso Spain",
    "Gastrocentr Perm Russia",
    "Department of Medical and Surgical Sciences Sant'orsola‐Malpighi University Hospital Bologna Italy",
    "Department of Internal Diseases Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University Kazan Russia",
    "Department of Primary Care and General Practice Kazan State Medical University Kazan Russia",
    "Interni Oddelek Diagnostic Centre Bled Slovenia",
    "Department of Gastroenterology Hospital Universitario de Cabueñes Gijón Asturias Spain",
    "Department of Gastroenterology SM‐Clinic Saint‐Petersburg Russia",
    "Department of Gastroenterology, Biodonostia Health Research Institute, Department of Medicine Universidad del País Vasco (UPV/EHU), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) San Sebastián Spain",
    "Department of Gastroenterology Chelyabinsk Regional Clinical Hospital Chelyabinsk Russia",
    "Department of Gastroenterology Hospital General Universitario de Valencia Valencia Spain",
    "First Clinical Medical Centre Kovrov Russia",
    "Saint‐Petersburg State Budgetary Institution Healthcare City Policlinic 38 Saint‐Petersburg Russia",
    "Department of Gastroenterology Hospital Quirón Marbella Marbella Spain",
    "Department of Hepatogastroenterology University of Study of Campania “L. Vanvitelli” Naples Italy",
    "Department of Gastroenterology Hospital Universitario Virgen de Valme Sevilla Spain",
    "Far Eastern State Medical University Khabarovsk Russia",
    "Department of Gastroenterology Hospital Universitario Sanitas La Moraleja Madrid Spain",
    "Faculty of Medicine Universidad CEU San Pablo Madrid Spain",
    "Department of Gastroenterology Portuguese Oncology Institute of Coimbra, RISE@CI‐IPO (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) Coimbra Portugal",
    "Department of Gastroenterology Hospital Universitario Río Hortega, Gerencia Regional de Salud de Castilla y León (SACYL) Valladolid Spain",
    "Department of Gastroenterology Hospital Universitario Virgen del Rocío Sevilla Spain",
    "Russian University of Medicine Moscow Russia",
    "Department of Gastroenterology Hospital Universitario Virgen Macarena Sevilla Spain",
    "Department of Gastroenterology Hospital 12 de Octubre Madrid Spain",
    "Department of Gastroenterology Hospital Universitario y Politécnico la Fe Valencia Spain",
    "Department of Gastroenterology Rostov State Medical University Rostov‐on‐Don Russia",
    "II Mechnikov North‐Western State Medical University Saint Petersburg Russia",
    "Department of Gastroenterology Hospital Universitario Santa Bárbara Ciudad Real Spain",
    "Department of Gastroenterology Hospital Universitario de Cruces Vizcaya Spain",
    "Department of Gastroenterology Hospital General Universitario Gregorio Marañón Madrid Spain",
    "Department of Gastroenterology Hospital Universitario de Burgos Burgos Spain",
    "Department of Pancreatic Biliary and Upper Digestive Tract Disorders, A. S. Loginov Moscow Clinical Scientific Center Moscow Russia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 137,
  "authors": [
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      "name": "Ismail Kirrout",
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      "name": "Olga P. Nyssen",
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      "name": "Maja Denkovski",
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      "name": "Aiman S. Sarsenbaeva"
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      "name": "Monica Perona"
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      "name": "Manuel Pabón‐Carrasco",
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      "name": "Sergey A. Alekseenko",
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      "name": "Óscar Núñez",
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      "name": "Miguel Areia",
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      "name": "Jesús Barrio",
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      "name": "Antonio Moreno Loro",
      "orcid": "0000-0003-4388-1058"
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      "name": "Dmitry N. Andreev"
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      ],
      "name": "Blas José Gómez Rodríguez",
      "orcid": "0000-0002-7428-032X"
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    {
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        31
      ],
      "name": "María Soledad Marcos",
      "orcid": "0009-0006-0190-7909"
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    {
      "affs": [
        32
      ],
      "name": "Inmaculada Ortiz‐Polo",
      "orcid": "0000-0002-9029-7375"
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    {
      "affs": [
        33
      ],
      "name": "Galina N. Tarasova"
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    {
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        34
      ],
      "name": "Igor Bakulin",
      "orcid": "0000-0002-6151-2021"
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    {
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      ],
      "name": "Mónica Sánchez Alonso"
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        36
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      "name": "Irene Arteagoitia"
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    {
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        37
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      "name": "Virginia Flores",
      "orcid": "0000-0001-8830-0136"
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      "name": "Manuel Jiménez‐Moreno",
      "orcid": "0000-0002-3898-8101"
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    {
      "affs": [
        39
      ],
      "name": "Dmitry S. Bordin",
      "orcid": "0000-0003-2815-3992"
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    {
      "name": "Antonio Gasbarrini",
      "orcid": "0000-0002-6230-1779"
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    {
      "name": "Ricardo Marcos‐Pinto"
    },
    {
      "name": "Wojciech Marlicz",
      "orcid": "0000-0002-2649-5967"
    },
    {
      "name": "Perminder S. Phull",
      "orcid": "0000-0002-1296-3803"
    },
    {
      "name": "Marino Venerito",
      "orcid": "0000-0001-8581-0974"
    },
    {
      "name": "Doron Boltin",
      "orcid": "0000-0003-3357-613X"
    },
    {
      "name": "Lyudmila Boyanova",
      "orcid": "0000-0001-9622-0873"
    },
    {
      "affs": [
        1
      ],
      "name": "Pablo Parra",
      "orcid": "0009-0002-8597-2206"
    },
    {
      "name": "Leticia Moreira",
      "orcid": "0000-0002-4518-8591"
    },
    {
      "name": "Francis Mégraud",
      "orcid": "0000-0002-2481-1612"
    },
    {
      "name": "Colm O'Morain",
      "orcid": "0000-0002-1847-6782"
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      "name": "Nuria Montes",
      "orcid": "0000-0001-9526-2772"
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    {
      "affs": [
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      ],
      "name": "Javier P. Gisbert",
      "orcid": "0000-0003-2090-3445"
    },
    {
      "name": "Natalia N. Dekhnich"
    },
    {
      "name": "Natalia N. Dekhnich"
    },
    {
      "name": "Pilar Mata‐Romero"
    },
    {
      "name": "Natalia Valerievna Bakulina"
    },
    {
      "name": "Alla G. Kononova"
    },
    {
      "name": "Giuseppe Losurdo"
    },
    {
      "name": "Judith Gomez‐Camarero"
    },
    {
      "name": "Alma Keco‐Huerga"
    },
    {
      "name": "Pablo M. Wolfe García"
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    {
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  ],
  "bibtex": "https://research.draconitic.com/paper/5sw7frmz8f4c3.bib",
  "cited_by": 0,
  "doi": "10.1111/hel.70169",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735993/",
  "id": "5sw7frmz8f4c3",
  "issns": [
    "1083-4389",
    "1523-5378"
  ],
  "landing_url": "https://doi.org/10.1111/hel.70169",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2715|Helicobacter pylori-related gastroenterology studies"
    ]
  ],
  "openalex": "W7225315785",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hel.70169",
  "pmcid": "PMC13735993",
  "pmid": "42984476",
  "published": "2026-11-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5sw7frmz8f4c3.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:33Z",
      "native_id": "PMC13735993",
      "source": "pmc",
      "url": "https://doi.org/10.1111/hel.70169"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Helicobacter pylori-related gastroenterology studies",
      "subfield": "general"
    }
  ],
  "title": "Lack of Usefulness of Literature‐Based Helicobacter pylori Resistance Data for Predicting First‐Line Empirical Treatment Effectiveness in the European Registry on H. pylori Management (Hp‐EuReg)",
  "title_text": "Lack of Usefulness of Literature‐Based Helicobacter pylori Resistance Data for Predicting First‐Line Empirical Treatment Effectiveness in the European Registry on H. pylori Management (Hp‐EuReg)",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:33Z",
  "url": "https://research.draconitic.com/paper/5sw7frmz8f4c3",
  "venue": "Helicobacter",
  "versions": []
}