{
  "abstract": "Background: Neuroimaging may help characterize brain and contextual factors associated with substance use during development. The ABCD study supports investigation of developmental pathways relevant to substance use [1]. Objective: To synthesize original ABCD publications examining MRI measures in relation to substance use and substance-related exposures. Methods: The authors screened all 2,700 publications in the ABCD corpus. Original empirical articles reporting an MRI measure of any modality and a substance use variable were eligible; methodological, conceptual, review, and commentary articles were excluded. Imaging modality, brain measures, substances, design, and association direction were extracted for descriptive synthesis. Results: The evidence considered spans morphology, white matter microstructure, resting-state connectivity, and task activation. Findings concerning youth initiation, prenatal exposure, and familial liability address distinct developmental questions. Family history and stressful life events feature in the white matter literature [2]. Findings vary by modality, exposure definition, and temporal direction, and include null associations. Conclusions: The literature suggests distributed and context-dependent neuroimaging associations. Observational designs, overlapping participants, confounding, and analytic heterogeneity limit causal interpretation and assessment of independent replication. The findings support further longitudinal investigation but do not establish a validated MRI screening tool.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "Shervin Assari",
      "orcid": "0000-0002-5054-6250"
    },
    {
      "name": "Jordan Ray"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5t7hswbctdkfz.bib",
  "cited_by": 0,
  "doi": "10.21203/rs.3.rs-11484087/v1",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734279/",
  "id": "5t7hswbctdkfz",
  "issns": [
    "2693-5015"
  ],
  "landing_url": "https://doi.org/10.21203/rs.3.rs-11484087/v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2713|Substance Abuse Treatment and Outcomes"
    ]
  ],
  "openalex": "W7223936732",
  "pdf_url": "https://www.researchsquare.com/article/rs-11484087/latest.pdf",
  "pmcid": "PMC13734279",
  "pmid": "42990774",
  "published": "2026-10-27",
  "publisher": "American Journal Experts",
  "ris": "https://research.draconitic.com/paper/5t7hswbctdkfz.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:53Z",
      "native_id": "PMC13734279",
      "source": "pmc",
      "url": "https://doi.org/10.21203/rs.3.rs-11484087/v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Substance Abuse Treatment and Outcomes",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Neuroimaging Correlates of Adolescent Substance Use: A Systematic Review of the Adolescent Brain Cognitive Development Study",
  "title_text": "Neuroimaging Correlates of Adolescent Substance Use: A Systematic Review of the Adolescent Brain Cognitive Development Study",
  "type": "preprint",
  "updated_at": "2026-11-08T12:23:53Z",
  "url": "https://research.draconitic.com/paper/5t7hswbctdkfz",
  "venue": "Research Square",
  "versions": []
}