{
  "abstract": "Structured lifestyle modification is the guideline-mandated foundation of lipid management but is rarely delivered in routine care. We evaluated lipodia, a fully self-guided digital health application providing structured lifestyle support, in a pragmatic randomised controlled trial conducted online. Adults with LDL-cholesterol above their risk-adapted target (n = 278) were randomised 1:1 to usual care plus lipodia or usual care alone. After six months, lipodia significantly reduced LDL-cholesterol relative to usual care (adjusted between-group difference in relative change -3.9%; p = 0.029), with nearly twice as many users achieving a clinically meaningful reduction of at least 10% (41.7% versus 23.8%; p = 0.002). lipodia also significantly improved patient activation, non-HDL-cholesterol, and health-related quality of life, with high uptake, low attrition, and no adverse device effects. As a self-guided tool, lipodia provides a scalable and guideline-concordant means of delivering structured lifestyle support that is rarely available in routine care.",
  "abstract_shown": true,
  "affiliations": [
    "GAIA AG"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "A. Riepenhausen"
    },
    {
      "name": "C. Ekerdt"
    },
    {
      "name": "B. Meyer"
    },
    {
      "name": "K. Jauch-Chara"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5t7r0zha686wg.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.15.26363103",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.15.26363103v1.full",
  "id": "5t7r0zha686wg",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.15.26363103v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "cardiovascular medicine"
    ],
    [
      "openalex",
      "3600|Mobile Health and mHealth Applications"
    ]
  ],
  "openalex": "W7213414690",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.15.26363103v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5t7r0zha686wg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "10.64898/2026.09.15.26363103",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.15.26363103v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:cardiovascular medicine",
      "subfield": "cardiovascular"
    }
  ],
  "title": "A self-guided digital health application for LDL-cholesterol reduction in adults with hypercholesterolaemia (the DIGICHOL randomised controlled trial)",
  "title_text": "A self-guided digital health application for LDL-cholesterol reduction in adults with hypercholesterolaemia (the DIGICHOL randomised controlled trial)",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:42Z",
  "url": "https://research.draconitic.com/paper/5t7r0zha686wg",
  "venue": "medRxiv",
  "versions": []
}