{
  "abstract": "This single‐center randomized controlled trial assessed the efficacy and safety of the ramucirumab plus nab‐paclitaxel, lobaplatin, and S‐1(RNPLS) regimen for conversion therapy in unresectable advanced gastric cancer. Seventy patients were equally assigned to receive either ramucirumab, nab‐paclitaxel, lobaplatin, and S‐1(RNPLS) therapy or nab‐paclitaxel, lobaplatin, and S‐1(NPLS) chemotherapy alone. Primary endpoints included pathological complete response (pCR) and secondary endpoints encompassed R0 resection rate, objective response rate (ORR), the disease control rate (DCR), progression‐free survival (PFS), overall survival (OS), duration of response (DOR), and adverse events (AE). Although the difference in pCR rate was statistically insignificant between the two groups, the RNPLS group achieved significantly higher ORR, DCR, and R0 resection rate. Moreover, the RNPLS regimen yielded prolonged PFS, longer duration of response, and promising preliminary OS. While hypertension occurred more frequently in the RNPLS group, the incidence of grade ≥3 AEs was low and comparable in both cohorts. This exploratory single‐center randomized trial showed preliminary favorable efficacy of RNPLS regimen for conversion therapy in unresectable advanced gastric cancer with manageable toxicity.\n\nTrial Registration: ClinicalTrials.gov: NCT06169410",
  "abstract_shown": true,
  "affiliations": [
    "Department of Digestive Surgery Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China",
    "Department of General Surgery Yulin Hospital Affiliated to the First Affiliated Hospital of Xi'an Jiaotong University Yulin China",
    "Department of Pharmaceutics and Pharmacy Administration School of Pharmacy Air Force Medical University Xi'an Xi'an China",
    "Xi'an Medical University Xi'an China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Juan Wang",
      "orcid": "0000-0001-7153-3603"
    },
    {
      "affs": [
        2
      ],
      "name": "Wei Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Guanghui Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Shushang Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Longxing Jiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Shu Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Chaosheng Peng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuxuan Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Huade Huo"
    },
    {
      "affs": [
        0
      ],
      "name": "Haolin Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaohua Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianjun Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5tmrtxzqp8xqx.bib",
  "cited_by": 0,
  "doi": "10.1002/mco2.70958",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732106/",
  "id": "5tmrtxzqp8xqx",
  "issns": [
    "2688-2663"
  ],
  "landing_url": "https://doi.org/10.1002/mco2.70958",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2730|Gastric Cancer Management and Outcomes"
    ]
  ],
  "openalex": "W7225245125",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mco2.70958",
  "pmcid": "PMC13732106",
  "pmid": "42984816",
  "published": "2026-11-03",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/5tmrtxzqp8xqx.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:09Z",
      "native_id": "PMC13732106",
      "source": "pmc",
      "url": "https://doi.org/10.1002/mco2.70958"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Gastric Cancer Management and Outcomes",
      "subfield": "oncology"
    }
  ],
  "title": "Efficacy and Safety of ramucirumab Combined With Nab‐paclitaxel, Lobaplatin, and S‐1 in Conversion Therapy for Unresectable Advanced Gastric Cancer: Preliminary Results of Conversion Therapy Cohort of RNPLS‐01 Trial",
  "title_text": "Efficacy and Safety of ramucirumab Combined With Nab‐paclitaxel, Lobaplatin, and S‐1 in Conversion Therapy for Unresectable Advanced Gastric Cancer: Preliminary Results of Conversion Therapy Cohort of RNPLS‐01 Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:09Z",
  "url": "https://research.draconitic.com/paper/5tmrtxzqp8xqx",
  "venue": "MedComm",
  "versions": []
}