{
  "abstract": "A visible-light-promoted, triphenylphosphine-mediated protocol for the direct O-selective etherification of 1,2-diketones is reported. Using NHPI esters as radical precursors, this method provides an efficient route to sterically congested ethers under mild conditions. The strategy exhibits compatibility with various tertiary alkyl radicals and 1,2-diketone derivatives. Mechanistic studies support a radical-mediated pathway, and adaptation to a photochemical continuous-flow platform enables improved efficiency, scalability, and operational control.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, University of Leuven (KU Leuven, Celestijnenlaan 200F, Leuven, Belgium, B-3001",
    "Peoples’ Friendship University of Russia (RUDN University, Miklukho-Maklaya street 6, Moscow, Russia, 117198",
    "Department of Chemistry and Biochemistry",
    "University of Missouri - St. Louis"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shengkun Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Sita Claesen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Erik V. Van der Eycken"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Upendra K. Sharma",
      "orcid": "0000-0001-7489-2337"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5tn18ytgv7999.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15006666/v2",
  "fulltext_url": null,
  "id": "5tn18ytgv7999",
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  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15006666/v2",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
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  "openalex": "W7222239834",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15006666/v2",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/5tn18ytgv7999.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15006666",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15006666/v3"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Visible-light-Enabled O-Selective Radical Etherification of 1,2-Dicarbonyl Compounds for the Synthesis of Sterically Congested Ethers",
  "title_text": "Visible-light-Enabled O-Selective Radical Etherification of 1,2-Dicarbonyl Compounds for the Synthesis of Sterically Congested Ethers",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:26Z",
  "url": "https://research.draconitic.com/paper/5tn18ytgv7999",
  "venue": "ChemRxiv",
  "versions": []
}