{
  "abstract": "Mitogens trigger cell-cycle entry by activating E2F at the restriction point, which is followed by B-MYB/FOXM1 activation and progression to mitosis. How mitogens control continued cycling and cell-cycle exit after the restriction point is not well-understood. By developing an E2F and B-MYB/FOXM1 dual transcriptional biosensor system, we show that S/G2 phase duration is set by timed mitogen-regulated B-MYB/FOXM1 activation, while E2F activity gradually declines before mitosis. As a striking consequence, rapid B-MYB/FOXM1 activation shortens S/G2, delivering high mitotic E2F activity to daughter cells which keeps them cycling. Delayed B-MYB/FOXM1 activation prolongs S/G2, depleting mitotic E2F which drives daughters to quiescence. When S/G2 is further prolonged, partially activated B-MYB/FOXM1 frequently reverts, triggering mitotic bypass and polyploid quiescence. Thus, B-MYB/FOXM1 governs a tri-directional (G2 restriction point) where cells commit to continued cycling through early B-MYB/FOXM1 activation; cell-cycle exit through delayed B-MYB/FOXM1 activation; or mitotic bypass by B-MYB/FOXM1 inactivation.",
  "abstract_shown": true,
  "affiliations": [
    "Weill Cornell Medicine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "T. MEYER"
    },
    {
      "name": "D. Rosenthal"
    },
    {
      "name": "T. Tsuruoka"
    },
    {
      "name": "V. Govindaraj"
    },
    {
      "name": "Y. Konagaya"
    },
    {
      "name": "B. Gong"
    },
    {
      "name": "S. Upadhya"
    },
    {
      "name": "N. Ratnayeke"
    },
    {
      "name": "D. Saha"
    },
    {
      "name": "W. Xia"
    },
    {
      "name": "M. Teruel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5ttwpabwxsy3a.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.21.753170",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753170v1.full",
  "id": "5ttwpabwxsy3a",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753170v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cell biology"
    ],
    [
      "openalex",
      "2730|Cancer-related Molecular Pathways"
    ]
  ],
  "openalex": "W7214056571",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753170v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5ttwpabwxsy3a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:57Z",
      "native_id": "10.64898/2026.09.21.753170",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753170v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "Parental B-MYB/FOXM1 controls mitotic E2F to determine daughter cell fate",
  "title_text": "Parental B-MYB/FOXM1 controls mitotic E2F to determine daughter cell fate",
  "type": "preprint",
  "updated_at": "2026-10-30T12:24:30Z",
  "url": "https://research.draconitic.com/paper/5ttwpabwxsy3a",
  "venue": "bioRxiv",
  "versions": []
}