{
  "abstract": "2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Olivia Morris"
    },
    {
      "name": "J. Gregory"
    },
    {
      "name": "M. Kadirvel"
    },
    {
      "name": "Fiona Henderson"
    },
    {
      "name": "A. Blykers"
    },
    {
      "name": "Adam Mcmahon"
    },
    {
      "name": "Mark Taylor"
    },
    {
      "name": "David Allsop"
    },
    {
      "name": "Stuart Allan"
    },
    {
      "name": "J. Grigg"
    },
    {
      "name": "Herve Boutin"
    },
    {
      "name": "Christian Prenant"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5v2brv2vgzjkr.bib",
  "cited_by": 12,
  "doi": "10.1016/j.apradiso.2016.07.023",
  "fulltext_url": null,
  "id": "5v2brv2vgzjkr",
  "issns": [
    "0969-8043",
    "1872-9800"
  ],
  "landing_url": "https://hal.science/hal-05789835v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.radio"
    ],
    [
      "openalex",
      "2741|Radiopharmaceutical Chemistry and Applications"
    ]
  ],
  "openalex": "W2491205768",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S0969804316304183/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/5v2brv2vgzjkr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:52Z",
      "native_id": "hal-05789835",
      "source": "hal",
      "url": "https://hal.science/hal-05789835v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.radio",
      "subfield": "inorganic"
    }
  ],
  "title": "Development & automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide",
  "title_text": "Development & automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:52Z",
  "url": "https://research.draconitic.com/paper/5v2brv2vgzjkr",
  "venue": "Applied Radiation and Isotopes",
  "versions": []
}