{
  "abstract": "Purpose of review\n\nLittle is known about the underlying cause contributing to the association between Osteoporosis (OP) and Alzheimer's disease (AD). This review highlights the emerging role of sclerostin, a protein mainly produced by osteocytes, in the newly discovered crosstalk between bone and brain, with a focus on its potential contribution to the relationship between OP and AD.Recent findings\n\nCirculating sclerostin levels increase with aging and are positively associated with brain amyloid-β burden in older adults. Studies demonstrate that elevated sclerostin can cross the blood-brain barrier, promote amyloid-β peptide deposition, and impair synaptic plasticity by suppressing Wnt/β-catenin signalling, whereas sclerostin inhibition restores neuronal plasticity and attenuates AD pathology. Sclerostin represents a promising target in the bone-brain interaction pathway. Its dual role as a measurable circulating biomarker and a modifiable component offers new opportunities for early risk assessment and therapeutic repurposing. Future longitudinal and interventional studies are essential to confirm the association between sclerostin and risk of AD, and to clarify whether targeting sclerostin can delay the onset of the disease or modify its trajectory.",
  "abstract_shown": true,
  "affiliations": [
    "School of Biomedical Sciences, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.",
    "Centre for Translational Orthopaedic Research, School of Biomedical Sciences, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.",
    "Department of Orthopaedic Surgery, Royal Perth Hospital, Wellington Street, Perth, WA, 6000, Australia.",
    "Department of Surgery, Medical School, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.",
    "Department of Orthopaedic Surgery, Fremantle and Fiona Stanley Hospitals, Perth, WA, 6150, Australia.",
    "Department of Orthopaedic Surgery, The Orthopaedic Research Foundation of Western Australia, Perth, WA, 6010, Australia.",
    "Division of Surgery, The University of Western Australia, Perth, WA, 6009, Australia.",
    "Perron Institute for Neurological and Translational Science, The University of Western Australia, 8 Verdun St, Nedlands, WA, 6009, Australia.",
    "Centre for Translational Orthopaedic Research, School of Biomedical Sciences, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia. minghao.zheng@uwa.edu.au.",
    "Perron Institute for Neurological and Translational Science, The University of Western Australia, 8 Verdun St, Nedlands, WA, 6009, Australia. minghao.zheng@uwa.edu.au.",
    "Centre for Translational Orthopaedic Research, School of Biomedical Sciences, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia. jun.yuan@perron.uwa.edu.au.",
    "Perron Institute for Neurological and Translational Science, The University of Western Australia, 8 Verdun St, Nedlands, WA, 6009, Australia. jun.yuan@perron.uwa.edu.au."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lorelé Gagiano"
    },
    {
      "affs": [
        1
      ],
      "name": "Ziming Chen"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "William G Blakeney"
    },
    {
      "affs": [
        4,
        5,
        6
      ],
      "name": "Christopher Jones",
      "orcid": "0000-0001-7283-626X"
    },
    {
      "affs": [
        7
      ],
      "name": "Frank Mastaglia"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Minghao Zheng"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Jun Yuan",
      "orcid": "0000-0001-6542-4654"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5vbbmwx5eh2h2.bib",
  "cited_by": 0,
  "doi": "10.1007/s11914-026-00993-y",
  "fulltext_url": "https://europepmc.org/articles/PMC13687117",
  "id": "5vbbmwx5eh2h2",
  "issns": [
    "1544-1873",
    "1544-2241"
  ],
  "landing_url": "https://europepmc.org/article/MED/42905237",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7223144874",
  "pdf_url": "https://europepmc.org/articles/PMC13687117?pdf=render",
  "pmcid": "PMC13687117",
  "pmid": "42905237",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5vbbmwx5eh2h2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42905237",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42905237"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Osteoporosis and Alzheimer's Disease: The Role of Sclerostin.",
  "title_text": "Osteoporosis and Alzheimer's Disease: The Role of Sclerostin.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/5vbbmwx5eh2h2",
  "venue": "Current osteoporosis reports",
  "versions": []
}