{
  "abstract": "BACKGROUND: Acute mesenteric ischemia (AMI) remains associated with high mortality despite prompt revascularization, suggesting that downstream ischemia-reperfusion injury contributes to poor outcomes. However, the microvascular mechanisms underlying this process are not entirely defined. METHODS: We analyzed admission blood samples from patients with arterial AMI and non-ischemic controls enrolled in the SURVIBIO diagnostic study (NCT03518099). We also investigated thrombo-inflammatory responses in a murine superior mesenteric artery occlusion (SMAO) model. In mice, intravital microscopy was used to directly visualize mesenteric microcirculatory flow and thrombo-inflammatory events during ischemia-reperfusion. RESULTS: Patients with AMI display a marked systemic thrombo-inflammatory profile, characterized by elevated inflammatory markers, neutrophil activation, platelet activation, and alterations in coagulation-related proteins, which are closely mirrored in the SMAO model. Intravital microscopy reveals a dissociation between arterial and microvascular reperfusion: while arteriolar flow partially recovers after recanalization, venular perfusion remains severely impaired and is associated with early blood cell stasis and stable venular thrombus formation. Thrombi develop through a sequential process initiated during ischemia and amplified during reperfusion. CONCLUSION: Together, these findings suggest that venular-centered thrombo-inflammation is closely associated with microvascular dysfunction and intestinal injury in arterial AMI. This work provides a framework for targeting thrombo-inflammatory pathways beyond arterial reperfusion that may extend to other clinical forms of AMI, including non-occlusive mesenteric ischemia (NOMI).",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Déborah François"
    },
    {
      "name": "Lambert Kernanet"
    },
    {
      "name": "Melinda Bajul"
    },
    {
      "name": "Abigail Brami"
    },
    {
      "name": "Véronique Arocas"
    },
    {
      "name": "Marie-Christine Bouton"
    },
    {
      "name": "Dominique Cazals-Hatem"
    },
    {
      "name": "Kevin Guedj"
    },
    {
      "name": "Benoit Ho-Tin-Noé"
    },
    {
      "name": "Olivier Corcos"
    },
    {
      "name": "Yacine Boulaftali"
    },
    {
      "name": "Alexandre Nuzzo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5vhy988ce219a.bib",
  "cited_by": 0,
  "doi": "10.1038/s43856-026-01878-y",
  "fulltext_url": null,
  "id": "5vhy988ce219a",
  "issns": [
    "2730-664X"
  ],
  "landing_url": "https://hal.science/hal-05790373v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2746|Abdominal vascular conditions and treatments"
    ]
  ],
  "openalex": "W7204469777",
  "pdf_url": "https://www.nature.com/articles/s43856-026-01878-y_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-28",
  "publisher": "Nature",
  "ris": "https://research.draconitic.com/paper/5vhy988ce219a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
      "native_id": "hal-05790373",
      "source": "hal",
      "url": "https://hal.science/hal-05790373v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Abdominal vascular conditions and treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Venular-centered thrombo-inflammation drives microvascular failure after arterial recanalization in acute mesenteric ischemia",
  "title_text": "Venular-centered thrombo-inflammation drives microvascular failure after arterial recanalization in acute mesenteric ischemia",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:53Z",
  "url": "https://research.draconitic.com/paper/5vhy988ce219a",
  "venue": "Communications Medicine",
  "versions": []
}