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  "abstract": "In this Guidelines and Guidance article, Wonsuk Yoo and John P.A. Ioannidis outline why research using large datasets faces threats to validity, highlighting four main statistical pitfalls and providing guidance and worked examples on how to mitigate against them.",
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    "School of Nursing and Health Studies, Division of Biostatistics/Bioinformatics, Department of Public Health Sciences, TCO Program, Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, Florida, United States of America.",
    "Meta-Research Innovation Center at Stanford (METRICS), Stanford University, California, United States of America.",
    "Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.",
    "Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California, United States of America.",
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  "title": "Addressing threats to validity in large dataset research",
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