{
  "abstract": "Background\n\nManagement of super-elderly patients (aged ≥ 80 years) with gastric cancer (GC) has become an increasingly important clinical issue. We aimed to evaluate the prognostic significance of preoperative \"hemoglobin, albumin, lymphocyte, and platelet\" (HALP) scores, which may reflect both tumor- and host-related conditions, in super-elderly patients with GC.Methods\n\nThis study included 507 super-elderly patients who underwent curative gastrectomy for GC at 10 hospitals. HALP scores were calculated as follows: hemoglobin × albumin × lymphocytes/platelets. We evaluated the prognostic significance and clinical robustness of the HALP score.Results\n\nPreoperative HALP scores ranged from 1.628 to 289.201 (median, 50.795), and the optimal cutoff value for predicting overall survival (OS) was 42.382, based on receiver operating characteristic curve analysis. Multivariate analysis identified that male sex, high preoperative carcinoembryonic antigen levels, poor performance status, pT3/4, pN(+), and low HALP scores (hazard ratio [HR], 2.23; 95% confidence interval, 1.63-3.04; p < 0.001) were independent risk factors for poor OS. We demonstrated the robustness of the prognostic significance of the HALP score using quartile, continuous variable, leave-one-center-out, and subgroup analyses. In addition, a low HALP score was independently associated with worse cancer-specific survival (HR, 2.08) and other-cause mortality (HR, 2.39), suggesting that the HALP score may reflect both tumor- and host-related conditions in super-elderly patients with GC.Conclusion\n\nThe HALP score appears to be a clinically useful and robust prognostic biomarker that may contribute to prognostic stratification and clinical decision-making in super-elderly patients with GC undergoing curative gastrectomy.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Digestive Surgery, Department of Surgery Kyoto Prefectural University of Medicine Kyoto Japan.",
    "Department of Surgery North Medical Center Kyoto Prefectural University of Medicine Kyoto Japan.",
    "Department of Digestive Surgery Japanese Red Cross Kyoto Daini Hospital Kyoto Japan.",
    "Department of Surgery Kyoto Chubu Medical Center Kyoto Japan.",
    "Department of Surgery Fukuchiyama City Hospital Kyoto Japan.",
    "Department of Surgery Kyoto Saiseikai Hospital Kyoto Japan.",
    "Department of Surgery Ayabe City Hospital Kyoto Japan.",
    "Department of Surgery National Hospital Organization Maizuru Medical Center Kyoto Japan.",
    "Department of Surgery Maizuru Kyosai Hospital Kyoto Japan.",
    "Department of Surgery Japanese Red Cross Society Maizuru, Hospital Kyoto Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hiroyuki Inoue",
      "orcid": "0000-0002-5879-9826"
    },
    {
      "affs": [
        0
      ],
      "name": "Takeshi Kubota",
      "orcid": "0000-0002-2246-3028"
    },
    {
      "affs": [
        0
      ],
      "name": "Toshiyuki Kosuga"
    },
    {
      "affs": [
        0
      ],
      "name": "Keiji Nishibeppu"
    },
    {
      "affs": [
        0
      ],
      "name": "Shutaro Sumiyoshi"
    },
    {
      "affs": [
        1
      ],
      "name": "Junichi Hamada"
    },
    {
      "affs": [
        2
      ],
      "name": "Kazuya Takabatake"
    },
    {
      "affs": [
        3
      ],
      "name": "Keita Katsurahara"
    },
    {
      "affs": [
        4
      ],
      "name": "Yosuke Ariyoshi"
    },
    {
      "affs": [
        5
      ],
      "name": "Koji Miyagawa"
    },
    {
      "affs": [
        6
      ],
      "name": "Sojin Sai"
    },
    {
      "affs": [
        7
      ],
      "name": "Yoshiki Itokawa"
    },
    {
      "affs": [
        8
      ],
      "name": "Tomoya Hatakeyama"
    },
    {
      "affs": [
        9
      ],
      "name": "Fumiaki Ochi"
    },
    {
      "affs": [
        0
      ],
      "name": "Hirotaka Konishi",
      "orcid": "0000-0002-4899-8944"
    },
    {
      "affs": [
        0
      ],
      "name": "Hitoshi Fujiwara"
    },
    {
      "affs": [
        0
      ],
      "name": "Atsushi Shiozaki",
      "orcid": "0000-0003-3739-160X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5vqjt8j5v1n0s.bib",
  "cited_by": 0,
  "doi": "10.1002/ags3.70300",
  "fulltext_url": "https://europepmc.org/articles/PMC13694431",
  "id": "5vqjt8j5v1n0s",
  "issns": [
    "2475-0328"
  ],
  "landing_url": "https://europepmc.org/article/MED/42927056",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7223294563",
  "pdf_url": "https://europepmc.org/articles/PMC13694431?pdf=render",
  "pmcid": "PMC13694431",
  "pmid": "42927056",
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5vqjt8j5v1n0s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927056",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927056"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "Prognostic Significance and Clinical Robustness of the HALP Score in Super-Elderly Patients Undergoing Curative Gastrectomy for Gastric Cancer: A Multicenter Retrospective Cohort Study.",
  "title_text": "Prognostic Significance and Clinical Robustness of the HALP Score in Super-Elderly Patients Undergoing Curative Gastrectomy for Gastric Cancer: A Multicenter Retrospective Cohort Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/5vqjt8j5v1n0s",
  "venue": "Annals of gastroenterological surgery",
  "versions": []
}