{
  "abstract": "Background\n\nPremature ovarian failure (POF) is a complex endocrine disorder that severely impairs female fertility. Cisplatin, a commonly used chemotherapeutic agent, has been identified as a major risk factor for POF in young women. This study aimed to investigate the protective effects and underlying mechanisms of the mitochondria-targeted peptide elamipretide (SS31) in a cisplatin-induced mouse model of POF.Methods\n\nPOF was established via intraperitoneal cisplatin (2 mg/kg, 7 days), followed by SS31 treatment (10 mg/kg, 3 weeks).Results\n\nSS31 treatment significantly alleviated cisplatin-induced ovarian damage and reversed key pathological features of POF. Mice treated with SS31 exhibited more rapid recovery in body weight, increased ovarian size and weight, improved ovarian morphology, and a significantly higher number of follicles at various developmental stages compared to the model group. SS31 also normalized serum hormone levels, reduced oxidative stress, restored mitochondrial membrane potential, and improved mitochondrial morphology in oocytes and granulosa cells. Mechanistically, SS31 activated the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway in ovarian tissues.Conclusion\n\nThe mitochondria-targeted peptide SS31 effectively ameliorates cisplatin-induced POF in mice by enhancing antioxidant defenses and preserving mitochondrial function. These findings suggest that SS31 is a promising therapeutic candidate for the clinical management of POF and provide new insights into antioxidant-based interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Center of Women's and Children's Health Medical Research and Technology Innovation, Sichuan Provincial Women's and Children's Hospital/The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, China.",
    "Key Laboratory of Fertility Preservation and Promotion, Sichuan Provincial Women's and Children's Hospital/The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China.",
    "Key Laboratory for Minimally Invasive/Non-Invasive Diagnosis and Treatment of Female Reproductive System Diseases and Lifelong Reproductive Health Protection, Sichuan Provincial Women's and Children's Hospital/The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China.",
    "College of Laboratory Medicine, Chengdu Medical College, Chengdu, China.",
    "Reproductive Laboratory, Meishan Women and Children's Hospital, Alliance Hospital of West China Second University Hospital, Meishan, China.",
    "School of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.",
    "Key Laboratory of Reproductive Medicine, Sichuan Provincial Women's and Children's Hospital/The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yuhong Zhao"
    },
    {
      "affs": [
        3
      ],
      "name": "Heqiu Yan"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Li Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Lei"
    },
    {
      "affs": [
        4
      ],
      "name": "Ningjing Li"
    },
    {
      "affs": [
        5
      ],
      "name": "Jun Liu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xia Bai"
    },
    {
      "affs": [
        6
      ],
      "name": "Weiwei Zhi"
    },
    {
      "affs": [
        5
      ],
      "name": "Min Jiang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Li Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Guohui Zhang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        5
      ],
      "name": "Weixin Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5w4nbks39a5tw.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1960111",
  "fulltext_url": "https://europepmc.org/articles/PMC13677905",
  "id": "5w4nbks39a5tw",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898512",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Reproductive Biology and Fertility"
    ]
  ],
  "openalex": "W7220418831",
  "pdf_url": "https://europepmc.org/articles/PMC13677905?pdf=render",
  "pmcid": "PMC13677905",
  "pmid": "42898512",
  "published": "2026-10-05",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5w4nbks39a5tw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898512",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898512"
    },
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1960111",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1960111/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Reproductive Biology and Fertility",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Mitochondria-targeted peptide elamipretide alleviates cisplatin-induced ovarian failure by activating the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway.",
  "title_text": "Mitochondria-targeted peptide elamipretide alleviates cisplatin-induced ovarian failure by activating the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:06Z",
  "url": "https://research.draconitic.com/paper/5w4nbks39a5tw",
  "venue": "Frontiers in pharmacology",
  "versions": []
}