{
  "abstract": "Aims: Whether and how benzene (a ubiquitous environmental pollutant posing substantial public health concerns) exposure contributes to glycemic dyshomeostasis and type 2 diabetes (T2DM) remain unclear. Methods: Among 3422 Chinese adults from the Wuhan-Zhuhai cohort, urinary N-Acetyl-S-(phenyl)- l -cysteine (PMA; dependable benzene exposure biomarker) was repeatedly measured at baseline and 3-year follow-up to investigate its associations with glycemic homeostasis markers (fasting plasma glucose [FPG] and insulin [FPI], homeostasis model assessment of insulin resistance [HOMA-IR], insulin resistance [IR], and impaired fasting glucose [IFG]) and T2DM appropriately by performing general linear, logistic, and Poisson regression models. Oxidative stress (exhaled carbon monoxide [eCO]; urinary 8-hydroxy-2′-deoxyguanosine and 8-iso-prostaglandin-F2α; plasma protein carbonyl) and inflammation (plasma C-reactive protein [CRP]; mean platelet volume [MPV]; neutrophil-to-lymphocyte ratio [NLR]) biomarkers were detected to explore their roles by performing mediation and interaction analyses. Results: Cross-sectionally, positive PMA-FPG (β = 0.014, 95% confidence interval: 0.005∼0.024), PMA-FPI (0.076, 0.049∼0.104), PMA-HOMA-IR (0.090, 0.059∼0.122), PMA-IR (odds ratio = 1.516, 1.192∼1.929), PMA-IFG (1.653, 1.164∼2.343), and PMA-T2DM (1.445, 1.019∼2.045) associations were discovered. Longitudinally, positive PMA-FPG (β = 0.059, 0.016∼0.101) and PMA-HOMA-IR (quartile 4 vs. 1: 0.054, 0.002∼0.106; P trend = 0.041) associations were uncovered, and participants with consistently high PMA level had higher risks of incident IR (risk ratio = 2.513, 1.638∼3.857) and T2DM (2.834, 1.042∼7.708). PMA-CRP and PMA-MPV interactions on FPG, PMA-CRP interaction on IFG, and PMA-NLR interaction on T2DM were detected. 8-Hydroxy-2′-deoxyguanosine and eCO mediated 4.74% and 5.97% of the PMA-FPI and PMA-T2DM associations, respectively. Conclusions: Benzene exposure of general adults was linked to the development of glycemic dyshomeostasis and T2DM possibly through mediation by oxidative stress and interaction with inflammation.",
  "abstract_shown": true,
  "affiliations": [
    "Lucy Cavendish College, University of Cambridge, Cambridge, CB3 0BU, UK",
    "Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "Le Hong"
    },
    {
      "name": "Shuhui Wan"
    },
    {
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        0
      ],
      "name": "Wendi Shi"
    },
    {
      "name": "Jiahao Song"
    },
    {
      "name": "Wenshan Shi"
    },
    {
      "name": "Feifei Wang"
    },
    {
      "name": "Yani Xiong"
    },
    {
      "name": "Jie Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Da Shi"
    },
    {
      "name": "Pengfei Chen"
    },
    {
      "name": "Qing Liu"
    },
    {
      "name": "Zhiying Huo"
    },
    {
      "name": "Jinqiang Li"
    },
    {
      "name": "Haobin Feng"
    },
    {
      "name": "Bin Wang"
    },
    {
      "name": "Weihong Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5w7ejjbch5jy7.bib",
  "cited_by": 0,
  "doi": "10.1016/j.redox.2026.104434",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2213231726004337",
  "id": "5w7ejjbch5jy7",
  "issns": [
    "2213-2317"
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  "landing_url": "https://doi.org/10.1016/j.redox.2026.104434",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
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  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2213231726004337/pdf",
  "pmcid": "PMC13720378",
  "pmid": "42925723",
  "published": "2026-10-11",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/5w7ejjbch5jy7.ris",
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      "first_seen": "2026-10-30T13:44:51Z",
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      "field": "medicine",
      "origin": "openalex:2307|Health, Environment, Cognitive Aging",
      "subfield": "pharmacology-toxicology"
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  "title": "Benzene exposure in relation to the development of glycemic dysregulation and type 2 diabetes mediated by oxidative stress and aggravated by inflammation in a repeated-measure prospective cohort study of Chinese adults",
  "title_text": "Benzene exposure in relation to the development of glycemic dysregulation and type 2 diabetes mediated by oxidative stress and aggravated by inflammation in a repeated-measure prospective cohort study of Chinese adults",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:16Z",
  "url": "https://research.draconitic.com/paper/5w7ejjbch5jy7",
  "venue": "Redox Biology",
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}