{
  "abstract": "Background: Evidence suggests LINC01809 being involved in prostate cancer (PC). We studied LINC01089 functionality, the underlying mechanisms, and translational potential in PC.\n\nMethods: Multiple PC cohorts (local, TCGA, and others) were utilized. Human (DU145 and LNCaP) and murine (TRAMP-C2) PC cells were used to investigate LINC01089-derived oncogenic potential in vitro and in vivo.\n\nResults: LINC01089 upregulation occurred in PC, Gleason score 9–10 tumors and metastasis. LINC01089 stratified PC recurrence. Plasma collected from patients (n = 235) prior to treatment contained elevated LINC01089, which was further increased in higher Gleason PCs and modestly correlated with PSA score. LINC01089-positively correlated genes contained a 15-gene panel (Sig15) and were dominantly enriched in RNA splicing in multiple PC datasets, with three genes (DDX17, LUC7L3, and HNRNPH1/Overlap3) conserved. Overlap3 and Sig15 effectively stratified the recurrence risk of PC and poor prognosis across 9 other cancer types, and captured the tumors' RNA splicing property, a major mechanism contributing to androgen receptor (AR) variants. Ectopic LINC01089 enhanced DU145, LNCaP, and TRAMP-C2 PC cell proliferation, colony formation, and migration, and conferred LNCaP and TRAMP-C2 cell proliferation under androgen deprivation, along with AR upregulation in the nucleus. In C57BL/6 mice, TRAMP-C2 LINC01089 allografts grew faster and expressed increased nuclear AR, Ki67, and AKT activation. TRAMP-C2 LINC01089 allografts expressed higher levels of Overlap3 and some Sig15 genes.\n\nConclusion: LINC01089 facilitates PC. Overlap3 and Sig15 are novel prognostic biomarkers reflecting cancer-associated RNA splicing. Plasma LINC01089 displays PC diagnostic potential.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, McMaster University, Hamilton, ON, L8S 4K1, Canada",
    "The Research Institute of St Joe’s Hamilton, St Joseph’s Hospital, Hamilton, ON, L8N 4A6, Canada"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Sandra Vega Neira"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Damu Tang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5wc6hzzerree8.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bbadva.2026.100205",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696824/",
  "id": "5wc6hzzerree8",
  "issns": [
    "2667-1603"
  ],
  "landing_url": "https://doi.org/10.1016/j.bbadva.2026.100205",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1306|Cancer-related molecular mechanisms research"
    ]
  ],
  "openalex": "W7221754946",
  "pdf_url": null,
  "pmcid": "PMC13696824",
  "pmid": "42936122",
  "published": "2026-10-14",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/5wc6hzzerree8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:06Z",
      "native_id": "PMC13696824",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.bbadva.2026.100205"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer-related molecular mechanisms research",
      "subfield": "oncology"
    }
  ],
  "title": "The long non-coding RNA LINC01089 facilitates prostate cancer progression",
  "title_text": "The long non-coding RNA LINC01089 facilitates prostate cancer progression",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:05Z",
  "url": "https://research.draconitic.com/paper/5wc6hzzerree8",
  "venue": "BBA Advances",
  "versions": []
}