{
  "abstract": "Background: Hypofractionated radiotherapy has been successfully shown to reduce pain and skin lesion bleeding. In previously irradiated areas, the effect of hypofractionated radiotherapy (weekly 4 Gy radiotherapy to a total dose of 20 Gy) can be enhanced by hyperthermia: increasing temperatures in target areas up to 43 °C. Superficial hyperthermia in combination with radiotherapy is a proven and widely applied treatment for recurrent breast cancer and malignant melanoma. Literature on the use of radiotherapy to cause hemostasis of the skin is available; however, the role of hyperthermia in combination with radiotherapy for this indication is not yet described.\n\nShort communication: We present a 72-year old woman with a history of breast cancer with painful and bleeding cutaneous metastases in the right upper arm and right breast which had a large impact on her quality of life. The metastases progressed under T‑deruxtecan treatment, and she was referred for re-irradiation to control the bleeding skin. Hyperthermia was added as a tumor-selective radiosensitizer to the radiotherapy fractions to enhance irradiation. The main treatment goal was to reduce bleeding and itching of the cutaneous lesions. The patient was treated once a week with hyperthermia immediately followed by 4 Gy radiotherapy fractions for 5 consecutive weeks. Bleeding was already decreased during the treatment series and the skin healed within 4 weeks after therapy.\n\nConclusion: Treatment with 5 × 4 Gy radiotherapy combined with hyperthermia sessions was a successful palliative therapy for bleeding cutaneous metastases. The treatment schedule was well-tolerated and the skin fully recovered within 1 month.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "D. M. V. de Vries-Huizing",
      "orcid": "0000-0003-1967-8148"
    },
    {
      "affs": [
        0
      ],
      "name": "A. Holtmaat"
    },
    {
      "affs": [
        0
      ],
      "name": "M. W. Kolff",
      "orcid": "0000-0002-8654-8645"
    },
    {
      "affs": [
        0
      ],
      "name": "J. Crezee",
      "orcid": "0000-0002-7474-0533"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5wwqdn62nhpme.bib",
  "cited_by": 0,
  "doi": "10.1007/s00066-026-02536-x",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731711/",
  "id": "5wwqdn62nhpme",
  "issns": [
    "0179-7158",
    "1439-099X"
  ],
  "landing_url": "https://doi.org/10.1007/s00066-026-02536-x",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Short Communication"
    ],
    [
      "openalex",
      "1306|Breast Cancer Treatment Studies"
    ]
  ],
  "openalex": "W7165577205",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00066-026-02536-x.pdf",
  "pmcid": "PMC13731711",
  "pmid": "42329260",
  "published": "2026-06-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5wwqdn62nhpme.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:51Z",
      "native_id": "PMC13731711",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00066-026-02536-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Breast Cancer Treatment Studies",
      "subfield": "oncology"
    }
  ],
  "title": "Successful palliative hypofractionated radiotherapy with superficial hyperthermia for heavily pretreated cutaneous breast cancer lesions",
  "title_text": "Successful palliative hypofractionated radiotherapy with superficial hyperthermia for heavily pretreated cutaneous breast cancer lesions",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:51Z",
  "url": "https://research.draconitic.com/paper/5wwqdn62nhpme",
  "venue": "Strahlentherapie Und Onkologie",
  "versions": []
}