{
  "abstract": "Flow diverter (FD) implantation is standard for unruptured intracranial aneurysms (UIAs), but cerebrovascular complications persist. This nested study within a prospective multicenter cohort evaluates whether short-term, low-dose glucocorticoid use is associated with cerebrovascular outcomes after FD implantation. Propensity-score matching with exact matching on UIA location yielded 1327 patients (360 glucocorticoid-treated; 967 controls). Intravenous glucocorticoids, initiated within 2 hours of the FD procedure and administered for ≥2 days, were associated with fewer in-hospital cerebrovascular events (6.9% vs. 13.1%; adjusted odds ratio [aOR], 0.53) and major cerebrovascular events (4.7% vs. 12.4%; aOR, 0.37). Over a median 2-year follow-up, glucocorticoid use was also associated with fewer new-onset major cerebrovascular events (3.6% vs. 8.7%; adjusted hazard ratio, 0.41) and less in-stent stenosis (7.9% vs. 13.2%; aOR, 0.55). Findings remained robust in unmatched patients on sensitivity analyses. We demonstrate that perioperative glucocorticoid regimens may reduce cerebrovascular events and in-stent stenosis in FD-treated patients, warranting randomized trials.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "name": "Zhuohua Wen"
    },
    {
      "name": "Xiheng Chen"
    },
    {
      "name": "Xin Tong"
    },
    {
      "name": "Chi Huang"
    },
    {
      "name": "Mengshi Huang"
    },
    {
      "name": "Jiancheng Lin"
    },
    {
      "name": "Anqi Xu",
      "orcid": "0000-0003-0518-5473"
    },
    {
      "name": "Hanyan Yang",
      "orcid": "0009-0003-4830-795X"
    },
    {
      "name": "Xiru Zhang"
    },
    {
      "name": "Yuanqi Lin"
    },
    {
      "name": "Jiwan Huang"
    },
    {
      "name": "Runze Ge"
    },
    {
      "name": "Hao Yuan"
    },
    {
      "name": "Chao Peng"
    },
    {
      "name": "Yanchao Liu"
    },
    {
      "name": "Fa Jin"
    },
    {
      "name": "Shixing Su"
    },
    {
      "name": "Xin Zhang"
    },
    {
      "name": "Xifeng Li",
      "orcid": "0000-0003-4393-1916"
    },
    {
      "name": "Zongduo Guo"
    },
    {
      "name": "Ming Lv"
    },
    {
      "name": "Aihua Liu"
    },
    {
      "name": "Chuanzhi Duan"
    },
    {
      "name": "Xin Feng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5xa4zbxtfktbh.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78408-w",
  "fulltext_url": null,
  "id": "5xa4zbxtfktbh",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78408-w",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Intracranial Aneurysms: Treatment and Complications"
    ]
  ],
  "openalex": "W7222784081",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78408-w_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-17",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/5xa4zbxtfktbh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-78408-w",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78408-w"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Intracranial Aneurysms: Treatment and Complications",
      "subfield": "neurology"
    }
  ],
  "title": "Low-Dose Glucocorticoids Adjunctive to Flow Diverter Therapy for Unruptured Intracranial Aneurysms Improve Cerebrovascular Outcomes",
  "title_text": "Low-Dose Glucocorticoids Adjunctive to Flow Diverter Therapy for Unruptured Intracranial Aneurysms Improve Cerebrovascular Outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:38Z",
  "url": "https://research.draconitic.com/paper/5xa4zbxtfktbh",
  "venue": "Nature Communications",
  "versions": []
}