{
  "abstract": "Chronic diabetic wounds are characterized by persistent inflammation, elevated oxidative stress, and impaired angiogenesis. However, effective strategies that simultaneously elucidate the underlying mechanisms and enable precise interventions remain scarce. This study aims to identify the neutrophil extracellular traps (NETs)-mitochondrial dysfunction-pyroptosis pathway as a key driver of impaired angiogenesis in diabetic wounds and to construct an intelligent composite hydrogel with pH-responsiveness and monitoring functions. The system utilizes a pH-responsive oxidized astragalus polysaccharide-gelatin hydrogel matrix that loads and enables the on-demand release of composite particles containing selenium and the antimicrobial peptide Andersonin-W1. These particles inhibit NETs formation, improve mitochondrial function, and reduce pyroptosis. Additionally, the system incorporates pH-responsive fluorescent carbon dots for visual monitoring of the wound microenvironment. In vitro and in vivo experiments demonstrate that the composite hydrogel effectively modulates the pathological axis, accelerates diabetic wound healing, and simultaneously enables visualization of the wound microenvironment. Overall, by integrating clinical single-cell transcriptomic analyses with in vitro and in vivo experiments, this study elucidates the critical role of the NETs-mitochondrial dysfunction-pyroptosis axis in diabetic nonhealing wounds and proposes an integrated platform for visual surveillance and precision treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.",
    "Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.",
    "Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xin Dan"
    },
    {
      "affs": [
        0
      ],
      "name": "Han Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Songjie Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Pu Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yikun Ju"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiangjun Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Tong Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Lanjie Lei",
      "orcid": "0000-0003-1773-1646"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Xing Fan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5xasqwy37nzx9.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bioactmat.2026.09.022",
  "fulltext_url": "https://europepmc.org/articles/PMC13677966",
  "id": "5xasqwy37nzx9",
  "issns": [
    "2452-199X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898399",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7214040266",
  "pdf_url": "https://europepmc.org/articles/PMC13677966?pdf=render",
  "pmcid": "PMC13677966",
  "pmid": "42898399",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5xasqwy37nzx9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42898399",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898399"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Theranostic peptide-selenium hydrogel targeting NETs-mitochondrial dysfunction-pyroptosis axis for chronic diabetic wound repair.",
  "title_text": "Theranostic peptide-selenium hydrogel targeting NETs-mitochondrial dysfunction-pyroptosis axis for chronic diabetic wound repair.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/5xasqwy37nzx9",
  "venue": "Bioactive materials",
  "versions": []
}