{
  "abstract": "BACKGROUND: Fluoroquinolones (FQ) are broad-spectrum antibiotics effective against various infections. However, their use has been progressively restricted by guidelines due to safety concerns, leading to repeated reassessments of their indication. Despite a marked decline in prescriptions, misuse remains a concern. This study aimed to assess FQ prescribing indications in general practice in France and analyse their evolution between 2014 and 2023 in light of changing guidelines. METHODS: We conducted a descriptive observational study using data from the THIN® (The Health Improvement Network) database, managed by CEGEDIM-GERS DATA. This European database collects anonymized electronic health records from private practitioners in seven countries, including France since 2014. In 2023, the French panel included over 3 million patients and approximately 2000 general practitioners (GPs). Available data include administrative and medical information. Oral FQ prescriptions for patients aged≥20years were analyzed in 2014, 2019 and 2023 for compliance with five frameworks: marketing authorization (MA), SPILF 2015 (French Infectious Diseases Society), HAS 2016 (French National Authority of Health) and EMA 2018/2019 (European Medicines Agency). Results were stratified by sex, age, molecule and indication category. RESULTS: FQ prescriptions by GPs declines by 59% between 2014 and 2023. Compliance varied by reference: approximately 75% according to MA and SPILF versus less than 25% with more recent guidelines (HAS 2016 and EMA 2018/2019). Compliance was lower in women and patients aged≥75years. In 2023, the largest misuse was observed for urinary and prostate infections (from approximately 94% to 24%) due to changes affecting uncomplicated urinary tract infections in women. For respiratory or ear nose and throat (ENT) infections, compliance remained low (20-40%) across all references. CONCLUSIONS: Despite decreasing FQ use in general practice, many prescriptions remain non-compliant with updated recommendations, highlighting a persistent gap between clinical practices and evolving guidelines.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Lisa Dilange"
    },
    {
      "name": "Karima Hider-Mlynarz"
    },
    {
      "name": "Daniele Saade"
    },
    {
      "name": "Marie-Joëlle Jabagi"
    },
    {
      "name": "Marion Bertrand"
    },
    {
      "name": "Mahmoud Zureik"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5xfshftnt9ykr.bib",
  "cited_by": 1,
  "doi": "10.1016/j.therap.2026.04.001",
  "fulltext_url": null,
  "id": "5xfshftnt9ykr",
  "issns": [
    "0040-5957",
    "1958-5578"
  ],
  "landing_url": "https://hal.science/hal-05849873v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.imm"
    ],
    [
      "openalex",
      "2402|Antibiotic Use and Resistance"
    ]
  ],
  "openalex": "W7152430346",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42173712",
  "published": "2026-11-03",
  "publisher": "Elsevier Masson",
  "ris": "https://research.draconitic.com/paper/5xfshftnt9ykr.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:20:19Z",
      "native_id": "hal-05849873",
      "source": "hal",
      "url": "https://hal.science/hal-05849873v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.imm",
      "subfield": "immunology"
    }
  ],
  "title": "Indication-related misuse of oral fluoroquinolones in adults by general practitioners in France",
  "title_text": "Indication-related misuse of oral fluoroquinolones in adults by general practitioners in France",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:12Z",
  "url": "https://research.draconitic.com/paper/5xfshftnt9ykr",
  "venue": "Therapies",
  "versions": []
}