{
  "abstract": "Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), including long-acting semaglutide, are revolutionary anti-obesity therapies. However, emerging evidence indicates that weight loss may come at the expense of skeletal muscle mass, a tissue essential for mobility, metabolic regulation, and overall health. Here, we show that an inhibitor of the gerozyme 15-hydroxyprostaglandin dehydrogenase (PGDHi), which boosts PGE2 levels, increases skeletal muscle mass, strength, and regeneration in the presence of semaglutide. We find that in a high fat diet-induced mouse model of obesity, semaglutide alone induces significant loss of muscle mass, while retaining contractile function. However, muscle regeneration and recovery of strength post-injury are hindered by semaglutide. This regenerative deficit is due to impeded stem cell function, which is overcome if mice are treated with a combination of PGDHi and semaglutide. Our data show that GLP-1-mediated weight loss interferes with this key muscle-building function, which PGDHi co-treatment counteracts to promote proper muscle regeneration and restored strength.",
  "abstract_shown": true,
  "affiliations": [
    "Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford School of Medicine",
    "Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine",
    "Stanford Cardiovascular Institute, Stanford University School of Medicine",
    "Department of Pathology, Stanford University School of Medicine",
    "Department of Animal Science, University of California",
    "Arc Institute",
    "Stanford Diabetes Research Center, Stanford University School of Medicine"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Minas Nalbandian",
      "orcid": "0000-0002-1018-3483"
    },
    {
      "affs": [
        3
      ],
      "name": "Jameel Barkat Lone",
      "orcid": "0000-0003-4571-1335"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Emméran Le Moal",
      "orcid": "0009-0005-4723-5901"
    },
    {
      "affs": [
        0
      ],
      "name": "Ireh Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Kaitlin Jeuris"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Yutong Kelly Li",
      "orcid": "0009-0002-9341-5493"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Peggy E. Kraft"
    },
    {
      "affs": [
        4,
        3
      ],
      "name": "Meng Zhao",
      "orcid": "0000-0002-5415-8335"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kassie Koleckar"
    },
    {
      "affs": [
        3
      ],
      "name": "Zeyuan Zhang",
      "orcid": "0000-0002-6372-0086"
    },
    {
      "affs": [
        5,
        3,
        6
      ],
      "name": "Katrin J. Svensson",
      "orcid": "0000-0001-5376-5128"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Helen M. Blau",
      "orcid": "0000-0001-6503-5480"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5xhmehvgwxvt7.bib",
  "cited_by": 9,
  "doi": "10.1073/pnas.2606533123",
  "fulltext_url": null,
  "id": "5xhmehvgwxvt7",
  "issns": [
    "0027-8424",
    "1091-6490"
  ],
  "landing_url": "https://doi.org/10.1073/pnas.2606533123",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Muscle Physiology and Disorders"
    ]
  ],
  "openalex": "W7163149303",
  "pdf_url": "https://www.pnas.org/doi/pdf/10.1073/pnas.2606533123",
  "pmcid": "PMC13160160",
  "pmid": "42124647",
  "published": "2026-06-02",
  "publisher": "National Academy of Sciences",
  "ris": "https://research.draconitic.com/paper/5xhmehvgwxvt7.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T13:20:47Z",
      "native_id": "W7163149303",
      "source": "openalex",
      "url": "https://doi.org/10.1073/pnas.2606533123"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Muscle Physiology and Disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist–induced weight loss",
  "title_text": "15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist–induced weight loss",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:07Z",
  "url": "https://research.draconitic.com/paper/5xhmehvgwxvt7",
  "venue": "Proceedings of the National Academy of Sciences",
  "versions": []
}