{
  "abstract": "Motor impairment in parkinsonism extends beyond the classical triad to weakness and a reduced capacity to sustain motor output, whose neuromodulatory control is poorly resolved. The endocannabinoid system is a candidate regulator, but CB1 and CB2 receptors have not been separated within one preparation. Reserpine-treated adult female Swiss mice received vehicle, the CB1 antagonist AM251, or the CB2 antagonist AM630 into the lateral ventricle; catalepsy was recorded across three trials and neuromuscular performance in a grip force task. Both antagonists increased the force generated at task onset, by amounts these data cannot distinguish: AM630 by 53.9 gf (95% CI 22.5-85.3) and AM251 by 41.2 gf (95% CI 8.8-73.6). They separated on duration. AM251 increased grip time by 619 ms (95% CI 113-1125), whereas AM630 did not (-70 ms, 95% CI -560 to +421). An interaction contrast on the force-time balance followed from that difference: AM630 shifted the balance toward force (-2.03 SD, P = 0.008), AM251 did not (-0.36 SD, P = 0.66), and the two differed from each other by 1.67 SD (P = 0.022). AM251 also reduced the odds of a cataleptic response (OR 0.16, 95% CI 0.03-0.89). Adjusting for body mass left both force effects unchanged. The dissociation is therefore in the duration of effort rather than in its force: both antagonists raise force, and only CB1 blockade also extends the time over which it is maintained. Delivered intracerebroventricularly, these effects are central in origin but not anatomically localized.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory of Exercise Biology (LABIOEX), Department of Physical Therapy, Centro de Ciências, Tecnologias e Saúde, Federal University of Santa Catarina, Rua Pedro João Pereira 158, Centro Cívico, Araranguá, Santa Catarina 88905-120, Brazil.",
    "Instituto de Ensino e Pesquisa Remederi, Via Anchieta 1616, Vila Moinho Velho, São Paulo, São Paulo 04246-002, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Beatriz Carminati Dos Santos",
      "orcid": "0009-0004-6075-6587"
    },
    {
      "affs": [
        0
      ],
      "name": "Izabely Guedes da Rosa",
      "orcid": "0009-0004-2904-3757"
    },
    {
      "affs": [
        0
      ],
      "name": "Laíze de Freitas Mazzardo"
    },
    {
      "affs": [
        0
      ],
      "name": "Naiara de Souza Santos",
      "orcid": "0000-0002-5593-7197"
    },
    {
      "affs": [
        0
      ],
      "name": "Izabel Feltrin Fabro",
      "orcid": "0009-0001-1292-6711"
    },
    {
      "affs": [
        0
      ],
      "name": "Tatyana Nery",
      "orcid": "0000-0002-7187-8756"
    },
    {
      "affs": [
        0
      ],
      "name": "Amanda Leite Bastos Pereira",
      "orcid": "0000-0001-9416-1208"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Aderbal S Aguiar",
      "orcid": "0000-0002-6825-3333"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5xng0g0srbt1t.bib",
  "cited_by": 0,
  "doi": "10.1021/acsptsci.6c00206",
  "fulltext_url": "https://europepmc.org/articles/PMC13693562",
  "id": "5xng0g0srbt1t",
  "issns": [
    "2575-9108"
  ],
  "landing_url": "https://europepmc.org/article/MED/42921228",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2736|Cannabis and Cannabinoid Research"
    ]
  ],
  "openalex": "W7214802690",
  "pdf_url": "https://europepmc.org/articles/PMC13693562?pdf=render",
  "pmcid": "PMC13693562",
  "pmid": "42921228",
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5xng0g0srbt1t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42921228",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42921228"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Cannabis and Cannabinoid Research",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Central Blockade of Cannabinoid CB1 and CB2 Receptors Increases Force Generation in Reserpine-Treated Mice, but Only CB1 Blockade Extends the Duration of Effort.",
  "title_text": "Central Blockade of Cannabinoid CB1 and CB2 Receptors Increases Force Generation in Reserpine-Treated Mice, but Only CB1 Blockade Extends the Duration of Effort.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/5xng0g0srbt1t",
  "venue": "ACS pharmacology & translational science",
  "versions": []
}