{
  "abstract": "Intestinal fibrosis is a major complication of Crohn’s disease, for which targeted therapies remain unavailable. Fibrosis is defined by excess matrix deposition, which may result from inadequate phagocytic clearance, yet how phagocytosis shifts here is unclear. Using single-cell and spatial transcriptomics, we identify fibrosis-associated CD47hi fibroblasts coupled to SIRPAhi macrophages in fibrotic regions. Cell-cell communication analyses and neutralizing-antibody experiments identify interleukin-1β as a mediator of their crosstalk, forming a profibrotic niche characterized by phagocytic evasion. Genetic disruption of fibroblast Cd47 or macrophage Sirpa enhances fibroblast clearance and attenuates fibrosis. Mechanistically, checkpoint disruption reprograms macrophages toward an NRF2-associated pro-phagocytic state, linking enhanced clearance to the antifibrotic response. Furthermore, therapeutic antibody blockade of this checkpoint attenuates intestinal fibrosis in mouse models with schedule-dependent efficacy. Collectively, these findings support CD47-mediated phagocytic evasion as a key pathogenic mechanism in intestinal fibrosis and identify CD47-SIRPα blockade as a promising therapeutic target.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China",
    "Shanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiangyu Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingman Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Danshu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Sishen Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Mingji Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jia Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiming Zhuang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiaxin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qidi Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yizhou Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Youqiong Ye"
    },
    {
      "affs": [
        0
      ],
      "name": "Liwen Hong"
    },
    {
      "affs": [
        0
      ],
      "name": "Taojing Ran"
    },
    {
      "affs": [
        0
      ],
      "name": "Yao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Duowu Zou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5xpdx5segdbcp.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xcrm.2026.103103",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710380/",
  "id": "5xpdx5segdbcp",
  "issns": [
    "2666-3791"
  ],
  "landing_url": "https://doi.org/10.1016/j.xcrm.2026.103103",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2403|Phagocytosis and Immune Regulation"
    ]
  ],
  "openalex": "W7223025334",
  "pdf_url": null,
  "pmcid": "PMC13710380",
  "pmid": "42901146",
  "published": "2026-10-20",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/5xpdx5segdbcp.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:21Z",
      "native_id": "PMC13710380",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xcrm.2026.103103"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Phagocytosis and Immune Regulation",
      "subfield": "immunology"
    }
  ],
  "title": "CD47 fuels intestinal fibrosis by inducing fibroblast phagocytic evasion and represents a therapeutic target",
  "title_text": "CD47 fuels intestinal fibrosis by inducing fibroblast phagocytic evasion and represents a therapeutic target",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:21Z",
  "url": "https://research.draconitic.com/paper/5xpdx5segdbcp",
  "venue": "Cell Reports Medicine",
  "versions": []
}