{
  "abstract": "Objective: To investigate the dosimetric effects of target volume Anatomical Parameters on organ at risk (OAR) following breast-conserving surgery and subsequent radiotherapy in patients with right-sided breast cancer.\n\nMethods: A retrospective study was conducted on 33 patients who underwent post-breast-conserving surgery radiotherapy. The transverse diameter (TD), oblique diameter (OD), and the ratio of transverse diameter to oblique diameter (TOR) were measured at the nipple-center plane for all patients. Bivariate Pearson correlation analysis was used to examine the effects of TD, OD, and TOR on V 20Gy , V 5Gy , D mean of the affected lung; D mean and V 5Gy of heart; D mean of the right coronary artery (RCA); D mean of the left anterior descending artery (LAD); V 5Gy of the contralateral lung; and D mean of the contralateral breast.\n\nResults: OD and TD showed significant correlations with V 20Gy , V 5Gy , and D mean of the affected lung ( 0.5 < R < 0.7, P < 0.01 ); The TD was significantly correlated with Heart_D mean ( R = 0.58, P < 0.01 ), strongly correlated with RCA_D mean ( R = 0.45, P < 0.01 ), and strongly correlated with LAD_D mean ( R = 0.42, P < 0.05 ); The TOR was significantly correlated with Heart_D mean ( R = 0.47, P < 0.01 ), strongly correlated with LAD_D mean ( R = 0.47, P < 0.01 ).\n\nConclusion: Exploratory observational thresholds from our cohort: target volume with TD >8.00 cm or OD >19.56 cm indicates higher lung dose risk; TD >8.00 cm or TOR >0.47 indicates higher cardiac dose risk. These thresholds were not optimized by ROC analysis and cannot be directly used for clinical risk stratification; prospective validation is needed. Clinical planning should minimize heart and lung radiation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oncology, The People’s Hospital of Rongchang District",
    "Department of Pediatrics, Chongqing University Three Gorges Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lu Zou"
    },
    {
      "affs": [
        0
      ],
      "name": "Zeping Deng"
    },
    {
      "affs": [
        0
      ],
      "name": "Xingliang Liao"
    },
    {
      "affs": [
        1
      ],
      "name": "Ling Duan"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuefen Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5xxf8kv9278ff.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1944304",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1944304/full",
  "id": "5xxf8kv9278ff",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1944304/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
    ],
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      "openalex",
      "3108|Advanced Radiotherapy Techniques"
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  "openalex": "W7223707579",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1944304/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5xxf8kv9278ff.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1944304",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1944304/full"
    },
    {
      "first_seen": "2026-10-30T13:47:24Z",
      "native_id": "f245e9e14c7e4be4aa1f39cc633c0472",
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      "url": "https://doi.org/10.3389/fonc.2026.1944304"
    }
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  "subjects": [
    {
      "field": "physics",
      "origin": "openalex:3108|Advanced Radiotherapy Techniques",
      "subfield": "applied-instrumentation"
    }
  ],
  "title": "Dosimetric impact of target volume anatomical parameters on radiotherapy after right-sided breast-conserving surgery",
  "title_text": "Dosimetric impact of target volume anatomical parameters on radiotherapy after right-sided breast-conserving surgery",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:24Z",
  "url": "https://research.draconitic.com/paper/5xxf8kv9278ff",
  "venue": "Frontiers in Oncology",
  "versions": []
}