{
  "abstract": "Background\n\nThe clinical relevance of chronic total occlusion (CTO) revascularization in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel disease (MVD) remains uncertain.Methods\n\nIn this multicenter retrospective cohort study, 632 patients with NSTEMI, MVD, and CTO were included. Patients were categorized into a complete revascularization group involving successful CTO recanalization (CR-CTO, n = 119) and an incomplete revascularization group without successful CTO recanalization (ICR-CTO, n = 513). The primary endpoints were major adverse cardiovascular and cerebrovascular events (MACCE) and major adverse cardiovascular events (MACE).Results\n\nDuring a mean follow-up of 528 ± 201 days, the incidences of MACCE (11.8% vs. 28.5%) and MACE (7.6% vs. 24.2%) were significantly lower in the CR-CTO group than in the ICR-CTO group (both p < 0.001). In multivariable Cox regression analyses, CR-CTO was independently associated with lower risks of MACCE (hazard ratio [HR], 0.35; 95% confidence interval [CI], 0.20-0.61) and MACE (HR, 0.26; 95% CI, 0.13-0.51). Among patients without successful CTO recanalization, additional revascularization of non-CTO lesions was not associated with improved outcomes.Conclusions\n\nIn patients with NSTEMI, MVD, and CTO, complete revascularization involving successful CTO recanalization was associated with improved mid-term clinical outcomes. In contrast, additional revascularization of non-CTO lesions alone was not associated with a prognostic benefit when CTO lesions remained unrevascularized. These findings suggest that CTO revascularization status may warrant specific consideration when revascularization strategies are evaluated in this patient population.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Xuzhou Central Hospital, Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China.",
    "Department of Cardiology, Xuzhou Central Hospital, Southeast University, Xuzhou, Jiangsu, China.",
    "Department of Ultrasonography, Xuzhou Central Hospital, Southeast University, Xuzhou, Jiangsu, China.",
    "Department of Cardiology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China.",
    "Department of Cardiology, Cangzhou People's Hospital, Cangzhou, Hebei, China.",
    "Department of Information Center, Yuncheng Central Hospital, Yuncheng, Shanxi, China.",
    "Medical Innovation Research Division, Chinese PLA General Hospital, Beijing, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Wei Liu",
      "orcid": "0009-0006-2250-3508"
    },
    {
      "affs": [
        2
      ],
      "name": "Yuling Li",
      "orcid": "0009-0006-3861-2426"
    },
    {
      "affs": [
        3
      ],
      "name": "Wei Qin"
    },
    {
      "affs": [
        4
      ],
      "name": "Jixian Gao"
    },
    {
      "affs": [
        5
      ],
      "name": "Bo Liu"
    },
    {
      "affs": [
        6
      ],
      "name": "Chongyou Rao",
      "orcid": "0000-0002-6405-0862"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Bing Han",
      "orcid": "0000-0002-3523-0573"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5xxnk2798zka7.bib",
  "cited_by": 0,
  "doi": "10.1002/clc.70491",
  "fulltext_url": "https://europepmc.org/articles/PMC13688248",
  "id": "5xxnk2798zka7",
  "issns": [
    "0160-9289",
    "1932-8737"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910468",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Coronary Interventions and Diagnostics"
    ]
  ],
  "openalex": "W7223188678",
  "pdf_url": "https://europepmc.org/articles/PMC13688248?pdf=render",
  "pmcid": "PMC13688248",
  "pmid": "42910468",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5xxnk2798zka7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910468",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910468"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Coronary Interventions and Diagnostics",
      "subfield": "surgery"
    }
  ],
  "title": "Mid-Term Clinical Outcomes According to CTO Revascularization Status in Patients With NSTEMI and Multivessel Disease.",
  "title_text": "Mid-Term Clinical Outcomes According to CTO Revascularization Status in Patients With NSTEMI and Multivessel Disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/5xxnk2798zka7",
  "venue": "Clinical cardiology",
  "versions": []
}