{
  "abstract": "Accessible blood-based biomarkers remain needed for Alzheimer's disease (AD) screening and diagnosis. We investigated whether blood transient receptor potential canonical 6 (TRPC6) could serve as a potential biomarker for AD. We enrolled 1254 individuals, including 366 patients with AD, 735 cognitively unimpaired (CU) individuals, and 153 individuals with non-AD neurological disorders. All patients with AD were confirmed to be amyloid beta positive (Aβ+) by Aβ positron emission tomography (PET). Blood TRPC6 messenger RNA (mRNA) levels were measured in all participants. In a subset, Aβ PET imaging and plasma biomarker assessments were performed. Blood TRPC6 mRNA levels differed significantly among the CU, AD, and non-AD groups, with the lowest levels observed in patients with AD. TRPC6 mRNA levels were associated with regional Aβ deposition and showed diagnostic performance comparable to several established plasma biomarkers, although slightly inferior to phosphorylated tau 217. Blood TRPC6 mRNA is markedly reduced in AD and may represent an accessible and clinically relevant blood biomarker for AD.",
  "abstract_shown": true,
  "affiliations": [
    "National Clinical Research Center for Aging and Medicine, Huashan Hospital, State Key Laboratory of Medical Neurobiology Fudan University Shanghai China.",
    "Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science Fudan University Shanghai China.",
    "Institute of Neurology Huashan Hospital Fudan University Shanghai China.",
    "Department of Nuclear Medicine & PET Center Huashan Hospital, Fudan University Shanghai China.",
    "Department of Neurology Zhongshan Hospital, Fudan University Shanghai China.",
    "Department of Neurology and Institute of Neurology Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital Shanghai China.",
    "Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China.",
    "Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing China.",
    "Department of Neurology The First Affiliated Hospital of USTC, University of Science and Technology of China Hefei China.",
    "The State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science Fudan University Shanghai China.",
    "Department of Clinical Laboratory Beijing Tiantan Hospital Capital Medical University Beijing China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Mei Pu"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yutong Wen"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yujing Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Jing Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Xiaoli Pan"
    },
    {
      "affs": [
        5
      ],
      "name": "Gang Wang"
    },
    {
      "affs": [
        6
      ],
      "name": "Xia Li"
    },
    {
      "affs": [
        7
      ],
      "name": "Guihong Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Chuantao Zuo"
    },
    {
      "affs": [
        8
      ],
      "name": "Jiong Shi"
    },
    {
      "affs": [
        9
      ],
      "name": "Liliang Zhu"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Jie Wu"
    },
    {
      "affs": [
        5
      ],
      "name": "Rujing Ren"
    },
    {
      "affs": [
        4
      ],
      "name": "Xiaoqin Cheng"
    },
    {
      "affs": [
        6
      ],
      "name": "Shaowei Zhang"
    },
    {
      "affs": [
        5
      ],
      "name": "Jintao Wang"
    },
    {
      "affs": [
        10
      ],
      "name": "Shujing Liu"
    },
    {
      "affs": [
        6
      ],
      "name": "Ling Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Fei Huang"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Ding Ding"
    },
    {
      "affs": [
        3
      ],
      "name": "Yihui Guan"
    },
    {
      "affs": [
        4
      ],
      "name": "Chunjiu Zhong"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Qianhua Zhao"
    },
    {
      "affs": [
        0,
        1,
        9
      ],
      "name": "Yizheng Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5xyc7fd0xbzdj.bib",
  "cited_by": 0,
  "doi": "10.1002/dad2.70433",
  "fulltext_url": "https://europepmc.org/articles/PMC13740373",
  "id": "5xyc7fd0xbzdj",
  "issns": [
    "2352-8729"
  ],
  "landing_url": "https://europepmc.org/article/MED/42996798",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7225381227",
  "pdf_url": "https://europepmc.org/articles/PMC13740373?pdf=render",
  "pmcid": "PMC13740373",
  "pmid": "42996798",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5xyc7fd0xbzdj.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42996798",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996798"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Blood TRPC6 mRNA as a biomarker for Alzheimer's disease: a nationwide, multicenter study in China.",
  "title_text": "Blood TRPC6 mRNA as a biomarker for Alzheimer's disease: a nationwide, multicenter study in China.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/5xyc7fd0xbzdj",
  "venue": "Alzheimer's & dementia (Amsterdam, Netherlands)",
  "versions": []
}