{
  "abstract": "Skin wound healing is a complex, multicellular process essential for maintaining tissue integrity and homeostasis. Despite advances in biomaterial and cell-based therapies, the mechanisms by which adipose tissue regulates skin regeneration remain incompletely understood. Here, we identify adipocyte Kindlin-2 as a critical regulator of cutaneous wound repair. Adipocyte-specific deletion of Kindlin-2 markedly accelerates wound closure in mice by enhancing fibroblast proliferation, angiogenesis, and suppressing inflammation. Transplantation of visceral white adipose tissue (vWAT) from Kindlin-2-deficient mice similarly promotes wound healing, indicating an endocrine contribution of vWAT to skin regeneration. Mechanistically, loss of Kindlin-2 promotes E-cadherin proteolysis, resulting in increased release of a 33-kDa C-terminal fragment (CTF2) that activates {beta}-catenin signaling and induces transcriptional upregulation and secretion of insulin-like growth factor binding protein 2 (IGFBP2). Elevated circulating IGFBP2, in turn, stimulates integrin signaling in target cells to enhance wound repair. Pharmacological inhibition of {beta}-catenin signaling abrogated the healing advantage conferred by Kindlin-2 deficiency. Conversely, local delivery of IGFBP2 via lentiviral significantly accelerates wound closure in both wild-type C57BL/6 and diabetic ob/ob mice. Collectively, these findings uncover a previously unrecognized adipose-skin endocrine axis governed by Kindlin-2 and IGFBP2 that orchestrates tissue regeneration. Targeting this Kindlin-2/E-cadherin/{beta}-catenin/IGFBP2 pathway offers a promising therapeutic strategy for enhancing wound healing, particularly in chronic and diabetic wounds.",
  "abstract_shown": true,
  "affiliations": [
    "Southen University of Science and Technology"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Z. Ding"
    },
    {
      "name": "G. Ma"
    },
    {
      "name": "F. Wang"
    },
    {
      "name": "S. Cheng"
    },
    {
      "name": "P. Li"
    },
    {
      "name": "Y. Chen"
    },
    {
      "name": "L. Chen"
    },
    {
      "name": "M. Ouyang"
    },
    {
      "name": "A. Wu"
    },
    {
      "name": "H. Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "H. Cao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5y2mfvny9jv18.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.01.763554",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763554v1.full",
  "id": "5y2mfvny9jv18",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763554v1",
  "language": null,
  "licence": "CC-BY-ND",
  "licence_label": "CC BY-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "molecular biology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763554v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5y2mfvny9jv18.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:21:38Z",
      "native_id": "10.64898/2026.11.01.763554",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763554v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:molecular biology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Adipocyte Kindlin-2 Coordinates an E-cadherin/β-catenin/IGFBP2 Endocrine Axis to Regulate Skin Regeneration and Diabetic Wound Healing",
  "title_text": "Adipocyte Kindlin-2 Coordinates an E-cadherin/β-catenin/IGFBP2 Endocrine Axis to Regulate Skin Regeneration and Diabetic Wound Healing",
  "type": "preprint",
  "updated_at": "2026-11-05T00:21:08Z",
  "url": "https://research.draconitic.com/paper/5y2mfvny9jv18",
  "venue": "bioRxiv",
  "versions": []
}