{
  "abstract": "Introduction: Antioxidant-rich plant-derived compounds are increasingly investigated for their role in preventing oxidative stress and managing metabolic disorders. Centaurea pungens Pomel, an underexplored Saharan species, represents a potential source of dietary bioactive compounds with functional properties. Methods: This study aimed to evaluate the phytochemical composition and nutraceutical potential of C. pungens through integrated chemical, biological, and in silico approaches. Results: The ethanolic extract was characterized using UPLC-ESI-MS/MS, revealing a diverse phytochemical profile comprising flavonoids and phenolic acids, with major constituents including curcumin, beta-carotene, and myricetin derivatives. The extract exhibited notable antioxidant activity, with 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging (IC50 = 0.0706 ± 0.006 mg/mL) and hydrogen peroxide scavenging (IC50 = 0.1789 ± 0.083 mg/mL), alongside moderate metal-chelating capacity. The extract exhibited significant in vitro alpha-amylase inhibitory activity. Molecular docking and 300 ns molecular dynamics simulations further suggested that myricetin 3arabinoside may contribute to the observed inhibitory effect through stable interactions with the catalytic pocket of human pancreatic alpha-amylase.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "Randa Mlik"
    },
    {
      "name": "Mohamed Amine Fares"
    },
    {
      "name": "Nour Elhouda Mekhadmi"
    },
    {
      "name": "Asma Abid"
    },
    {
      "name": "Assia Bentahar"
    },
    {
      "name": "Walid Boussebaa"
    },
    {
      "name": "Slimane Ahmed Benmchih Ayada"
    },
    {
      "name": "Mohamed Kharsi"
    },
    {
      "name": "Makhlouf Sekour"
    },
    {
      "name": "Samia Hamouda"
    },
    {
      "name": "Wafa Ali Eltayb"
    },
    {
      "name": "Han Yu"
    },
    {
      "name": "Mohnad Abdalla"
    },
    {
      "name": "Ali Alsalme"
    },
    {
      "name": "Mikhael Bechelany"
    },
    {
      "name": "Ahmed Barhoum"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5yhbqzy8ym0ga.bib",
  "cited_by": 0,
  "doi": "10.3389/fnut.2026.1866954",
  "fulltext_url": null,
  "id": "5yhbqzy8ym0ga",
  "issns": [
    "2296-861X"
  ],
  "landing_url": "https://hal.umontpellier.fr/hal-05770489v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "2712|Natural Antidiabetic Agents Studies"
    ]
  ],
  "openalex": "W7204600448",
  "pdf_url": "https://hal.umontpellier.fr/hal-05770489/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-28",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/5yhbqzy8ym0ga.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "hal-05770489",
      "source": "hal",
      "url": "https://hal.umontpellier.fr/hal-05770489v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Natural Antidiabetic Agents Studies",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Centaurea pungens Pomel as a potential nutraceutical source: Polyphenol-rich profile, antioxidant capacity, and inhibition of digestive α-amylase",
  "title_text": "Centaurea pungens Pomel as a potential nutraceutical source: Polyphenol-rich profile, antioxidant capacity, and inhibition of digestive α-amylase",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:43Z",
  "url": "https://research.draconitic.com/paper/5yhbqzy8ym0ga",
  "venue": "Frontiers in Nutrition",
  "versions": []
}