{
  "abstract": "Background: At-risk mental states (ARMS), involving subclinical attenuated psychotic experiences, occur in the general population with persistence rates above 30%, and may substantially affect quality of life, well-being and global functioning. Cannabis use has been linked to the onset, persistence and intensity of attenuated psychotic symptoms, whereas other evidence identifies trauma as a mediating factor. This study examined the potential effect and degree of interaction of cannabis use patterns in a general population sample with a history of traumatic experiences during childhood and adolescence. Methods: A selective ex post facto cross-sectional survey design was used. Adults residing in Uruguay with no prior psychopathological diagnosis (n = 652, 66.3% women, M = 31.9 years, SD = 8.5) completed a controlled online survey assessing traumatic experiences, negative symptoms, aberrant salience, ideas of reference and cannabis use patterns. Results: Statistically significant correlations confirmed a dual interaction of traumatic experiences, and of the frequency and grams of cannabis used, on attenuated psychotic symptoms. Traumatic experiences explained R2 = .202 of the variance in attenuated psychotic symptomatology, more than the dose (R2 = .14) and frequency (R2 = .048) of cannabis use. Combining the trauma effect with both use-pattern effects yielded a model with better fit and greater explained variance (R2 = .252). Conclusions: Traumatic experiences during childhood and adolescence are positively associated with cannabis use and, to a greater extent, with attenuated psychotic symptoms (ARMS) such as ideas of reference, aberrant salience and negative symptoms, showing greater explanatory power than cannabis use.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Richard Rodriguez"
    },
    {
      "name": "Celia Ceballos-Munuera"
    },
    {
      "name": "Paul Ruiz"
    },
    {
      "name": "Juan F. Rodriguez-Testal"
    },
    {
      "name": "Álvaro Cabana"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5yyjywm8d1p3g.bib",
  "cited_by": 0,
  "doi": "10.31234/osf.io/vc4us_v1",
  "fulltext_url": null,
  "id": "5yyjywm8d1p3g",
  "issns": [],
  "landing_url": "https://osf.io/preprints/psyarxiv/vc4us_v1/",
  "language": null,
  "licence": "CC0-1.0",
  "licence_label": "CC0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/publicdomain/zero/1.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "bepress",
      "Clinical Psychology"
    ],
    [
      "bepress",
      "Psychiatry"
    ],
    [
      "bepress",
      "Social and Behavioral Sciences"
    ],
    [
      "openalex",
      "2736|Cannabis and Cannabinoid Research"
    ]
  ],
  "openalex": "W7222075020",
  "pdf_url": "https://osf.io/vc4us/download",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5yyjywm8d1p3g.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:37Z",
      "native_id": "vc4us",
      "source": "osf",
      "url": "https://osf.io/preprints/psyarxiv/vc4us_v1/"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "bepress:Clinical Psychology",
      "subfield": "psychiatry"
    }
  ],
  "title": "Trauma, Cannabis Use and Attenuated Psychotic Symptoms: A Mediation Model in the Uruguayan General Population",
  "title_text": "Trauma, Cannabis Use and Attenuated Psychotic Symptoms: A Mediation Model in the Uruguayan General Population",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:37Z",
  "url": "https://research.draconitic.com/paper/5yyjywm8d1p3g",
  "venue": "PsyArXiv",
  "versions": []
}