{
  "abstract": "Myocardial lipid remodeling in myocardial infarction (MI) remains insufficiently characterized in human myocardium. Using liquid chromatography–mass spectrometry, we analyzed left atrial appendage tissue from patients with and without MI undergoing cardiac surgery. MI was characterized by reduced phospholipid species containing omega-3 polyunsaturated fatty acids (PUFAs) and myristic acid, together with reduced diacylglycerol species containing omega-3 PUFAs. Reduced phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and plasmalogens were observed, whereas triacylglycerols were enriched. Loss of polyunsaturated phospholipids and accumulation of relatively saturated triacylglycerols indicate a shift toward neutral lipid storage in human MI myocardium.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiovascular Medicine, Juntendo University Shizuoka Hospital, Shizuoka, Japan",
    "Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan",
    "Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan",
    "Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan",
    "Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan",
    "Department of Cardiovascular Surgery, Juntendo University Graduate School of Medicine, Tokyo, Japan",
    "Laboratory of Bioregulatory Clinical Pharmacology, Faculty of Pharmacy, Juntendo University, Chiba, Japan",
    "Faculty of Health Science, Juntendo University, Tokyo, Japan",
    "Clinical Research Center, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tomoyuki Shiozawa"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Tomoyasu Kadoguchi"
    },
    {
      "affs": [
        3
      ],
      "name": "Hyeon-Cheol Lee-Okada"
    },
    {
      "affs": [
        4
      ],
      "name": "Kazunori Shimada"
    },
    {
      "affs": [
        5
      ],
      "name": "Satoshi Matsushita"
    },
    {
      "affs": [
        3
      ],
      "name": "Takehiko Yokomizo"
    },
    {
      "affs": [
        4,
        6
      ],
      "name": "Tetsuro Miyazaki"
    },
    {
      "affs": [
        4
      ],
      "name": "Tatsuro Aikawa"
    },
    {
      "affs": [
        4
      ],
      "name": "Hidemori Hayashi"
    },
    {
      "affs": [
        0
      ],
      "name": "Satoru Suwa"
    },
    {
      "affs": [
        5
      ],
      "name": "Atsushi Amano"
    },
    {
      "affs": [
        4
      ],
      "name": "Yuji Nakazato"
    },
    {
      "affs": [
        7
      ],
      "name": "Hiroyuki Daida"
    },
    {
      "affs": [
        5
      ],
      "name": "Minoru Tabata"
    },
    {
      "affs": [
        1,
        8
      ],
      "name": "Naoshi Fukui"
    },
    {
      "affs": [
        8
      ],
      "name": "Nobuho Tanaka"
    },
    {
      "affs": [
        8
      ],
      "name": "Hirotaka Tsuno"
    },
    {
      "affs": [
        4
      ],
      "name": "Tohru Minamino"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5zg703e24js88.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jmccpl.2026.100875",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13698078/",
  "id": "5zg703e24js88",
  "issns": [
    "2772-9761"
  ],
  "landing_url": "https://doi.org/10.1016/j.jmccpl.2026.100875",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Short Communication"
    ],
    [
      "openalex",
      "1303|Lipid metabolism and biosynthesis"
    ]
  ],
  "openalex": "W7220904490",
  "pdf_url": "https://europepmc.org/articles/PMC13698078?pdf=render",
  "pmcid": "PMC13698078",
  "pmid": "42935987",
  "published": "2026-10-07",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/5zg703e24js88.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:01Z",
      "native_id": "PMC13698078",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jmccpl.2026.100875"
    },
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42935987",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42935987"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1303|Lipid metabolism and biosynthesis",
      "subfield": "enzymology-metabolism"
    }
  ],
  "title": "Myocardial lipid remodeling in patients with myocardial infarction undergoing cardiac surgery",
  "title_text": "Myocardial lipid remodeling in patients with myocardial infarction undergoing cardiac surgery",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:35:00Z",
  "url": "https://research.draconitic.com/paper/5zg703e24js88",
  "venue": "Journal of Molecular and Cellular Cardiology Plus",
  "versions": []
}