{
  "abstract": "Introduction: Hematopoietic stem cell transplantation (HSCT) provides definitive treatment for many inborn errors of immunity (IEI). Although most children achieve full immune reconstitution, long-term psychosocial and quality-of-life outcomes in medically stable survivors remain insufficiently understood.\n\nMethods: Children aged 8–18 years with IEI who achieved complete immune recovery and had no chronic complications were included. Quality of life and psychological status were evaluated using the Pediatric Quality of Life Inventory (PedsQL-C) and the Revised Children’s Anxiety and Depression Scale (RCADS). Healthy children matched for age, sex, and sociodemographic background served as controls.\n\nResults: Thirty-six patients and 41 controls participated. Children post-HSCT had significantly lower physical, psychosocial, and total quality-of-life scores (p = 0.022, 0.015, 0.006) and higher depression scores (p = 0.027). One-quarter of school-aged patients were not attending school, and one-third of families restricted exposure to crowded environments.\n\nConclusion: Despite immune recovery, children remain vulnerable to psychosocial challenges. These findings support incorporation of routine psychological assessment and family counseling into long-term post-HSCT follow‑up.",
  "abstract_shown": true,
  "affiliations": [
    "Cerrahpasa Faculty of Medicine, Department of Pediatric Allergy and Immunology, Istanbul University-Cerrahpasa, Kocamustafapasa, Fatih, Istanbul, 34098 Türkiye",
    "Cerrahpasa Faculty of Medicine, Department of Pediatrics, Istanbul University-Cerrahpasa, Istanbul, Türkiye",
    "Department of Pediatric Allergy and Immunology, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye",
    "Faculty of Medicine, Department of Pediatrics, Division of Allergy and Immunology, Immune Deficiency Research and Application Center, Marmara University Hospital, Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, The Isil Berat Barlan Center for Translational Medicine, Istanbul, Türkiye",
    "Cerrahpasa Faculty of Medicine, Department of Child and Adolescent Psychiatry, Istanbul University-Cerrahpasa, Istanbul, Türkiye"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sezin Aydemir",
      "orcid": "0000-0002-5876-2601"
    },
    {
      "affs": [
        1
      ],
      "name": "Ekin Nurhan",
      "orcid": "0009-0000-7723-9165"
    },
    {
      "affs": [
        2
      ],
      "name": "Isilay Turan",
      "orcid": "0000-0003-1297-1923"
    },
    {
      "affs": [
        3
      ],
      "name": "Necmiye Keser Ozturk",
      "orcid": "0000-0003-2623-8626"
    },
    {
      "affs": [
        0
      ],
      "name": "Betul Gemici Karaaslan",
      "orcid": "0000-0002-0303-7146"
    },
    {
      "affs": [
        0
      ],
      "name": "Zeynep Meric",
      "orcid": "0000-0003-1792-1570"
    },
    {
      "affs": [
        2
      ],
      "name": "Selami Ulas",
      "orcid": "0000-0003-1486-9690"
    },
    {
      "affs": [
        3
      ],
      "name": "Sevgi Bilgic Eltan",
      "orcid": "0000-0003-0561-3343"
    },
    {
      "affs": [
        0
      ],
      "name": "Haluk Cezmi Cokuğras",
      "orcid": "0000-0002-0086-3936"
    },
    {
      "affs": [
        3
      ],
      "name": "Elif Karakoç Aydıner",
      "orcid": "0000-0003-4150-5200"
    },
    {
      "affs": [
        3
      ],
      "name": "Safa Baris",
      "orcid": "0000-0002-4730-9422"
    },
    {
      "affs": [
        3
      ],
      "name": "Ahmet Ozen",
      "orcid": "0000-0002-9065-1901"
    },
    {
      "affs": [
        2
      ],
      "name": "Cigdem Aydogmus",
      "orcid": "0000-0002-6036-7694"
    },
    {
      "affs": [
        0
      ],
      "name": "Esra Yucel",
      "orcid": "0000-0003-3712-2522"
    },
    {
      "affs": [
        4
      ],
      "name": "Gizem Durcan",
      "orcid": "0000-0002-7863-4551"
    },
    {
      "affs": [
        4
      ],
      "name": "Mesut Yavuz",
      "orcid": "0000-0002-6580-2093"
    },
    {
      "affs": [
        4
      ],
      "name": "Burak Dogangun",
      "orcid": "0000-0002-0106-8256"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayca Kiykim",
      "orcid": "0000-0001-5821-3963"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5zg7p2f1w59f0.bib",
  "cited_by": 0,
  "doi": "10.1007/s11845-026-04480-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13739990/",
  "id": "5zg7p2f1w59f0",
  "issns": [
    "0021-1265",
    "1863-4362"
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  "landing_url": "https://doi.org/10.1007/s11845-026-04480-2",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
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      "2403|Immunodeficiency and Autoimmune Disorders"
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  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s11845-026-04480-2.pdf",
  "pmcid": "PMC13739990",
  "pmid": "42287508",
  "published": "2026-06-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5zg7p2f1w59f0.ris",
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    {
      "first_seen": "2026-11-10T12:21:20Z",
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  "subjects": [
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      "field": "biology",
      "origin": "openalex:2403|Immunodeficiency and Autoimmune Disorders",
      "subfield": "immunology"
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  ],
  "title": "Beyond immune recovery: Quality of life and psychosocial challenges in children with inborn errors of immunity after transplantation",
  "title_text": "Beyond immune recovery: Quality of life and psychosocial challenges in children with inborn errors of immunity after transplantation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:21:20Z",
  "url": "https://research.draconitic.com/paper/5zg7p2f1w59f0",
  "venue": "Irish Journal of Medical Science",
  "versions": []
}