{
  "abstract": "Peripheral nerve injury (PNI) remains challenging due to oxidative stress and inflammation limiting stem cell therapy. Here, we developed an injectable, ROS-scavenging selenium nanoparticle (SeNP) hydrogel (SeNP-Gel) to protect adipose-derived stem cells (ADSCs) and enhance peripheral nerve repair. SeNP-Gel exhibited excellent biocompatibility, a porous structure, and favorable mechanical properties, effectively scavenging hydrogen peroxide and reducing oxidative stress to improve ADSC survival. In vitro, the hydrogel promoted Schwann cell migration, angiogenesis, and M2 microglial polarization, thereby alleviating neuroinflammation. In a rat sciatic nerve injury model, the ADSCs/SeNP-Gel composite synergistically accelerated axonal regeneration, myelination, and functional recovery, outperforming either component alone. This strategy integrates SeNPs, hydrogel, and ADSCs to coordinate oxidative stress modulation and immune microenvironment remodeling for PNI treatment.",
  "abstract_shown": true,
  "affiliations": [
    "The Third Hospital of Hebei Medical University , , No. 139 Ziqiang Road , ,",
    "Handan First Hospital , , No. 25 Congtai Road , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Meng Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiang Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Fengyu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Zheng Cheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinzhong Shao",
      "orcid": "0009-0006-4376-9292"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5zn16wv55j26h.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c05916",
  "fulltext_url": "https://europepmc.org/articles/PMC13688571",
  "id": "5zn16wv55j26h",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/41/63084/5447186/ROS-Scavenging-Selenium-Nanoparticle-Hydrogel",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2804|Nerve injury and regeneration"
    ]
  ],
  "openalex": "W7221054086",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c05916",
  "pmcid": "PMC13688571",
  "pmid": "42924023",
  "published": "2026-10-08",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/5zn16wv55j26h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c05916",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/41/63084/5447186/ROS-Scavenging-Selenium-Nanoparticle-Hydrogel"
    },
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42924023",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924023"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Nerve injury and regeneration",
      "subfield": "neuroscience"
    }
  ],
  "title": "ROS-Scavenging Selenium Nanoparticle Hydrogel Synergizes with Adipose-Derived Stem Cells to Promote Peripheral Nerve Repair",
  "title_text": "ROS-Scavenging Selenium Nanoparticle Hydrogel Synergizes with Adipose-Derived Stem Cells to Promote Peripheral Nerve Repair",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/5zn16wv55j26h",
  "venue": "ACS Omega",
  "versions": []
}