{
  "abstract": "Purpose\n\nTo evaluate the influence of surgical trauma-induced inflammation and surgery type or presence of appendicitis on the levels of the studied cytokines, CRP and cortisol as biomarkers.Methods\n\nA prospective study was performed of pediatric patients undergoing laparotomy or laparoscopy. The concentrations of cytokines were assessed using Luminex xMAP technology, CRP by immunoturbidimetric method, and cortisol by ELISA. Their levels were determined twice at four time points: at baseline, after 6-12 h postoperative (cortisol), 12-24 h (other markers apart from CRP), and 36-48 h (CRP).Results\n\nSignificant increases were observed in IL-6 (p = 0.001) and IL-10 (p = 0.034) in non-inflammatory patients undergoing laparotomy, and in IL-6 in inflammatory (p = 0.035) and non-inflammatory (p < 0.001) groups receiving laparoscopy. Significant increases in IL-8 (p = 0.020) and sTNFRII (p = 0.004) were demonstrated in patients with inflammation undergoing laparoscopy. Significant increased CRP levels were noted in all four examined subgroups (p = 0.003, p = 0.01, p < 0.001, p < 0.001).Conclusion\n\nsTNFRII, CRP and IL-6 are sensitive biomarkers of surgical trauma-induced inflammation. sTNFRII and CRP are reliable indicators of the presence of appendicitis. Laparotomy resulted in a greater increase in sTNFRII levels, whereas laparoscopy stimulated CRP production more strongly. The open surgery is characterized by earlier mechanical tissue injury than laparoscopy.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Medicine, Lazarski University, Warsaw, Poland.",
    "Polish Society of Burn Management, Cracow, Poland.",
    "Polish Mother's Health Center Institute, Lodz, Poland.",
    "Department of Epidemiology and Biostatistics, Chair of Social and Preventive Medicine, Medical University of Lodz, Lodz, Poland.",
    "Department of Intensive Care and Anesthesiology, 2nd Chair of Pediatrics, Central Clinical Hospital, Medical University of Lodz, Lodz, Poland.",
    "Department of Pediatric Surgery and Oncology, Chair of Surgical Pediatrics, Central Clinical Hospital, Medical University of Lodz, Lodz, Poland.",
    "Department of Pediatric Emergency Medicine, 2nd Chair of Pediatrics, Central Clinical Hospital, Medical University of Lodz, Lodz, Poland. janusz.sikora@umed.lodz.pl."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jakub Karawani",
      "orcid": "0009-0003-3818-938X"
    },
    {
      "affs": [
        1
      ],
      "name": "Leszek Marzec",
      "orcid": "0000-0002-8062-1311"
    },
    {
      "affs": [
        2
      ],
      "name": "Jarosław Sobczak",
      "orcid": "0000-0003-3267-3739"
    },
    {
      "affs": [
        3
      ],
      "name": "Monika Burzyńska",
      "orcid": "0000-0001-9875-7383"
    },
    {
      "affs": [
        4
      ],
      "name": "Anna Sikora",
      "orcid": "0000-0002-7641-3050"
    },
    {
      "affs": [
        5
      ],
      "name": "Przemysław Przewratil",
      "orcid": "0000-0003-4581-8853"
    },
    {
      "affs": [
        6
      ],
      "name": "Janusz P Sikora",
      "orcid": "0000-0003-0228-5823"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5zt1ajxk95qjq.bib",
  "cited_by": 0,
  "doi": "10.1007/s00383-026-06708-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13727907",
  "id": "5zt1ajxk95qjq",
  "issns": [
    "0179-0358",
    "1437-9813"
  ],
  "landing_url": "https://europepmc.org/article/MED/42970154",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2403|Inflammation biomarkers and pathways"
    ]
  ],
  "openalex": "W7225110519",
  "pdf_url": "https://europepmc.org/articles/PMC13727907?pdf=render",
  "pmcid": "PMC13727907",
  "pmid": "42970154",
  "published": "2026-11-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5zt1ajxk95qjq.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:43Z",
      "native_id": "MED:42970154",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42970154"
    },
    {
      "first_seen": "2026-11-06T12:23:42Z",
      "native_id": "PMC13727907",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00383-026-06708-9"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Inflammation biomarkers and pathways",
      "subfield": "immunology"
    }
  ],
  "title": "Selected interleukins, soluble TNF-α receptors, c-reactive protein and cortisol as biomarkers of surgical trauma-induced inflammation in children.",
  "title_text": "Selected interleukins, soluble TNF-α receptors, c-reactive protein and cortisol as biomarkers of surgical trauma-induced inflammation in children.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:00Z",
  "url": "https://research.draconitic.com/paper/5zt1ajxk95qjq",
  "venue": "Pediatric surgery international",
  "versions": []
}