{
  "abstract": "Behavioral time scale synaptic plasticity (BTSP) allows hippocampal CA1 neurons to form or shift place fields after a single plasticity-inducing plateau potential, but what determines when individual neurons become eligible for another plasticity event remains unclear. Here we propose that recent somatic spike history provides a cell-specific gate for plateau initiation, making neurons sensitive to rising activity after relative silence while suppressing repeated plasticity during sustained firing. In a two-compartment spiking model of CA1, this gate interacts with entorhinal input to create a feedback loop in which existing representations bias subsequent plateau locations. The resulting dynamics produce gradual place-field drift, reward-associated overrepresentation, recovery of environment-specific representations after remapping, and cross-day reinstatement. Our model further predicts that stronger residual activity biases subsequent plateaus toward previous field locations, a relationship we identify by reanalyzing experimental data. Thus, the expression of neural representations can help determine when and where they are subsequently rewritten.",
  "abstract_shown": true,
  "affiliations": [
    "RIKEN Center for Brain Science, Hierarchical Neural Computation RIKEN ECL Research Unit"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "A. C. Kurth"
    },
    {
      "name": "T. Asabuki"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/600j8pwxc5swb.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.15.751647",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751647v1.full",
  "id": "600j8pwxc5swb",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751647v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2805|Memory and Neural Mechanisms"
    ]
  ],
  "openalex": "W7213935808",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751647v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/600j8pwxc5swb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:33Z",
      "native_id": "10.64898/2026.09.15.751647",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751647v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Spike-history gating of plateau potentials enables closed-loop rewriting of CA1 representations",
  "title_text": "Spike-history gating of plateau potentials enables closed-loop rewriting of CA1 representations",
  "type": "preprint",
  "updated_at": "2026-10-30T12:23:33Z",
  "url": "https://research.draconitic.com/paper/600j8pwxc5swb",
  "venue": "bioRxiv",
  "versions": []
}