{
  "abstract": "With the explosion of chromosome-scale genome assemblies being generated in recent years, there is vast potential for comparative genomics analyses through detecting multi-genome synteny. While existing tools can detect synteny blocks between multiple genomes, their text-based outputs make it challenging to intuitively explore large-scale synteny patterns. Interpretable, information-rich and easy-to-use synteny visualization tools are imperative to enable important biological insights from the synteny block data output by the aforementioned utilities. Here, we present ntSynt-viz, a command-line tool for automated sorting, normalization, and plotting of multi-genome synteny blocks. We show how ntSynt-viz provides clearer and more easily interpretable chromosome painting ribbon plots compared to the state-of-the-art tools NGenomeSyn and plotsr when evaluating synteny between 14 human genomes, and compared to NGenomeSyn when comparing 9 hoverfly genomes. As plotsr is limited to comparing genomes with equal chromosome numbers, it was not applicable to the hoverfly dataset. Furthermore, we demonstrate how ntSynt-viz can also be applied to visualize syntenic patterns encoded in pangenome graphs, using a Minigraph-Cactus graph built from 16 Drosophila genomes. We expect that ntSynt-viz will provide crucial insights into large-scale synteny patterns between divergent genomes, thereby advancing research into key evolutionary questions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Basic and Translational Research, BC Cancer Research Institute , 675 W 10th Ave, BC, V5Z 1L3, Vancouver, BC ,",
    "BC Cancer Genome Sciences Centre",
    "Department of Medical Genetics, University of British Columbia , 6200 University Blvd, V6T 1Z4, Vancouver, BC ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Lauren Coombe",
      "orcid": "0000-0002-7518-2326"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "René L. Warren",
      "orcid": "0000-0002-9890-2293"
    },
    {
      "affs": [
        0,
        2,
        1
      ],
      "name": "İnanç Birol",
      "orcid": "0000-0003-0950-7839"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/600t63htkpf3r.bib",
  "cited_by": 24,
  "doi": "10.1093/jeb/voag079",
  "fulltext_url": null,
  "id": "600t63htkpf3r",
  "issns": [
    "1010-061X",
    "1420-9101"
  ],
  "landing_url": "https://doi.org/10.1093/jeb/voag079",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1311|Genome Rearrangement Algorithms"
    ]
  ],
  "openalex": "W4406541932",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42690038",
  "published": "2026-09-03",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/600t63htkpf3r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:46Z",
      "native_id": "W4406541932",
      "source": "openalex",
      "url": "https://doi.org/10.1093/jeb/voag079"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Genome Rearrangement Algorithms",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "ntSynt-viz: visualizing synteny patterns across multiple genomes",
  "title_text": "ntSynt-viz: visualizing synteny patterns across multiple genomes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:41Z",
  "url": "https://research.draconitic.com/paper/600t63htkpf3r",
  "venue": "Journal of Evolutionary Biology",
  "versions": []
}