{
  "abstract": "Anatomic location of white adipose tissue is a determinant of cardiometabolic risk. To understand differences within/between adipose depots, we generated 65,668 single-nucleus transcriptomes from human subcutaneous or intraabdominal adipose tissue (SAT/IAT). Unsupervised analysis reveals 26 adipose-resident cell clusters including two subpopulations of mature adipocytes, characterized by high vs. low expression of adipocyte maturation genes (ADIPOMAThi vs. ADIPOMATlo). ADIPOMATlo adipocytes demonstrate a low-differentiation, pro-inflammatory, and pro-fibrotic transcriptome. IAT-resident ADIPOMATlo were more abundant in higher BMI donors, while SAT-resident ADIPOMATlo associated with impaired glycemia. TSHZ3 is identified as a candidate regulator of ADIPOMATlo transcriptome. TSHZ3 knockdown in adipogenic progenitors inhibits differentiation, with downregulation of early adipogenic regulators (e.g., CEBPA/B, PPARG) and mature adipocyte genes. Heterozygous deletion of Tshz3 in mice reduces SAT and IAT weight. Here, we show that adipocyte subsets with distinct transcriptomic signature reside in human WAT; altered TSHZ3-mediated transcriptional regulation may contribute to low-maturation subpopulation linked to metabolic disease.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "name": "Vissarion Efthymiou"
    },
    {
      "name": "Adhideb Ghosh"
    },
    {
      "name": "Sean Kodani"
    },
    {
      "name": "Habib Muallem"
    },
    {
      "name": "Xavier Caubit"
    },
    {
      "name": "Waqar Ali"
    },
    {
      "name": "Lindsay Poulos"
    },
    {
      "name": "Henrique Camara"
    },
    {
      "name": "Anushka Gupta"
    },
    {
      "name": "Yasmine Belaidouni"
    },
    {
      "name": "A. Sina Booeshaghi"
    },
    {
      "name": "Shiyi Yang"
    },
    {
      "name": "Ruchir Rastogi"
    },
    {
      "name": "Farnaz Shamsi"
    },
    {
      "name": "Ashley Vernon"
    },
    {
      "name": "Laurent Fasano"
    },
    {
      "name": "Assaf Rudich"
    },
    {
      "name": "Aaron Streets"
    },
    {
      "name": "Yu-Hua Tseng"
    },
    {
      "name": "Mary Elizabeth Patti"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6036q09sxp1m7.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-75426-6",
  "fulltext_url": null,
  "id": "6036q09sxp1m7",
  "issns": [
    "2041-1723",
    "2041-1723"
  ],
  "landing_url": "https://hal.science/hal-05764286v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.bbm"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.bbm.gtp"
    ],
    [
      "hal",
      "2.sdv.mhep.em"
    ],
    [
      "openalex",
      "2737|Adipose Tissue and Metabolism"
    ]
  ],
  "openalex": "W7172552230",
  "pdf_url": "https://hal.science/hal-05764286/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-05",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/6036q09sxp1m7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "hal-05764286",
      "source": "hal",
      "url": "https://hal.science/hal-05764286v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "hal:2.sdv.bbm.gtp",
      "subfield": "proteomics-metabolomics"
    },
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.em",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Single-nucleus analysis of human white adipose tissue reveals adipocyte subsets with distinct metabolic profiles",
  "title_text": "Single-nucleus analysis of human white adipose tissue reveals adipocyte subsets with distinct metabolic profiles",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:41Z",
  "url": "https://research.draconitic.com/paper/6036q09sxp1m7",
  "venue": "Nature Communications",
  "versions": []
}