{
  "abstract": "Changes in gene expression during bacterial infection are the combined result of altered transcription and translation, with the latter comparatively understudied. Gram-negative bacteria rapidly trigger cytokine gene transcription in macrophages through the activation of pathogen-associated molecular pattern receptors, for example the detection of Salmonella lipopolysaccharide (LPS) from the bacterial cell envelope by Toll-like receptor 4 (TLR4). Here, through time-resolved parallel translatomic and transcriptomic profiling, we now show temporal TLR4-specific translational upregulation of cell signaling proteins in macrophages induced by Salmonella. While transcriptional upregulation of these genes is dampened through the activity of the Salmonella SPI-1 type 3 secretion system, a robust translational response remains. These data reveal an important host-pathogen translational regulatory network that modifies the innate immune response of macrophages to infection.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "George Wood"
    },
    {
      "name": "Rebecca Johnson"
    },
    {
      "name": "Matthew P. Brember"
    },
    {
      "name": "Filip Lastovka"
    },
    {
      "name": "Panagiotis Tourlomousis"
    },
    {
      "name": "Clare E. Bryant"
    },
    {
      "name": "Betty Y.-W. Chung",
      "orcid": "0000-0003-4384-285X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/60e72hq5rsgv3.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117901",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734781/",
  "id": "60e72hq5rsgv3",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03284-0",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "bacteriology"
    ],
    [
      "heading",
      "biological sciences"
    ],
    [
      "heading",
      "microbiology"
    ],
    [
      "openalex",
      "2403|Immune Response and Inflammation"
    ]
  ],
  "openalex": "W7223567249",
  "pdf_url": "https://www.cell.com/iscience/pdf/S2589-0042(26)03284-0.pdf",
  "pmcid": "PMC13734781",
  "pmid": "42990597",
  "published": "2026-10-25",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/60e72hq5rsgv3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117901",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03284-0"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117901",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226032840"
    },
    {
      "first_seen": "2026-11-09T12:20:36Z",
      "native_id": "PMC13734781",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.117901"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Toll-like receptor 4-driven translational reprogramming in macrophages is unaffected by Salmonella SPI-1 activity",
  "title_text": "Toll-like receptor 4-driven translational reprogramming in macrophages is unaffected by Salmonella SPI-1 activity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:36Z",
  "url": "https://research.draconitic.com/paper/60e72hq5rsgv3",
  "venue": "iScience",
  "versions": []
}