{
  "abstract": "Introduction\n\nMultiparametric magnetic resonance imaging (mpMRI) reduces the need for repeat biopsies in prostate cancer (PC) patients under active surveillance (AS). The prospective PROMM-AS trial confirmed reliable prediction of upgrading in ISUP Grade Group (GG) 1-2 PC. We report outcomes of men from the PROMM-AS trial undergoing deferred radical prostatectomy (RP) after radiologic or histopathologic progression, including short-term oncological follow-up.Material and methods\n\nThe primary endpoint was biochemical recurrence (BCR; PSA ≥0.1 ng/ml). Secondary endpoints included adverse pathology (AP; ISUP GG ≥3 and/or ≥pT3 at RP), PSA level at 12 months, and metastases. Differences between ISUP GG were evaluated using Fisher's exact test. Sensitivity, specificity, positive and negative predictive value to predict BCR and AP were calculated. Regression analyses using MRI and clinical variables were performed to analyze predictors of BCR and AP.Results\n\nOf 148 men, 28 (19%) - 10 GG1 and 18 GG2 - progressed (radiologic n=15, histopathologic n = 3, combined n = 10) and underwent RP within 24 months of trial duration. Median follow-up after RP was 24 months (IQR 15-38). Among 25 patients with ≥12 months follow-up, 92% achieved PSA <0.01 ng/ml at 12 months. BCR occurred in 4 patients (14%), AP in 9 (32%), and 1 patient (3.6%) developed pelvic lymph node metastasis. Gleason Pattern (GP) 4 at biopsy, PI-RADS, and PRECISE scores significantly predicted BCR, while GP4 percentage, percentage of positive cores and PI-RADS predicted AP.Conclusions\n\nThese findings support the oncological safety of MRI-guided AS in terms of BCR and development of metastases in selected GG1/2 PC patients. However, the rate of AP needs to be acknowledged in patient counseling.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, Medical Faculty, University of Düsseldorf, Germany.",
    "Division of Personalized Early Detection of Prostate Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.",
    "Department of Diagnostic and Interventional Radiology, Medical Faculty, University of Düsseldorf, Germany.",
    "Department of Diagnostic, Interventional Radiology and Nuclear Medicine, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.",
    "Department of Urology and Paediatric Urology, Elisabeth-Krankenhaus Rheydt, Staedtische Kliniken Moenchengladbach GmbH, Germany.",
    "Department of Urology, University Hospital Essen, Germany.",
    "Department of Radiology, University College London Hospitals NHS Foundation Trust, United Kingdom.",
    "Division of Surgery and Interventional Science, University College London, United Kingdom.",
    "Department of Urology, Kliniken Maria Hilf GmbH, Moenchengladbach, Germany.",
    "Institute of Pathology, Medical Faculty, University of Düsseldorf, Germany.",
    "Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany.",
    "Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Isabelle Busshoff"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rouvier Al-Monajjed"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Lars Schimmöller"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Christian Arsov"
    },
    {
      "affs": [
        2
      ],
      "name": "Birte Valentin"
    },
    {
      "affs": [
        0
      ],
      "name": "Jale Lakes"
    },
    {
      "affs": [
        2
      ],
      "name": "Tim Ullrich"
    },
    {
      "affs": [
        5
      ],
      "name": "Boris A Hadaschik"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Francesco Giganti"
    },
    {
      "affs": [
        0,
        8
      ],
      "name": "Markus Giessing"
    },
    {
      "affs": [
        9
      ],
      "name": "Tilman T Rau"
    },
    {
      "affs": [
        9
      ],
      "name": "Irene Esposito"
    },
    {
      "affs": [
        2,
        10
      ],
      "name": "Gerald Antoch"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Peter Albers"
    },
    {
      "affs": [
        2
      ],
      "name": "Matthias Boschheidgen"
    },
    {
      "affs": [
        0,
        11
      ],
      "name": "Jan Philipp Radtke"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/60h6jaj85dgbc.bib",
  "cited_by": 0,
  "doi": "10.5173/ceju.2025.0285",
  "fulltext_url": "https://europepmc.org/articles/PMC13681911",
  "id": "60h6jaj85dgbc",
  "issns": [
    "2080-4806",
    "2080-4873"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903620",
  "language": "eng",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Prostate Cancer Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7204953466",
  "pdf_url": "https://europepmc.org/articles/PMC13681911?pdf=render",
  "pmcid": "PMC13681911",
  "pmid": "42903620",
  "published": "2026-07-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/60h6jaj85dgbc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:59Z",
      "native_id": "MED:42903620",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903620"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Prostate Cancer Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Results of radical prostatectomy and short-term follow-up of men with ISUP GG 1 and 2 prostate cancer who underwent magnetic resonance imaging-guided active surveillance.",
  "title_text": "Results of radical prostatectomy and short-term follow-up of men with ISUP GG 1 and 2 prostate cancer who underwent magnetic resonance imaging-guided active surveillance.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:59Z",
  "url": "https://research.draconitic.com/paper/60h6jaj85dgbc",
  "venue": "Central European journal of urology",
  "versions": []
}