{
  "abstract": "Acid-responsive drug delivery systems have evolved into versatile platforms for achieving spatially and temporally controlled drug activation by exploiting pathological and intracellular acidity. Despite significant advances in prodrug- and carrier-based systems, key challenges remain, including pH heterogeneity, limited understanding of structure-property-function relationships, and translational barriers. Future efforts will focus on developing ultra-sensitive and programmable systems with precisely tunable response thresholds. The integration of multi-stimuli responsiveness, logic-gated release mechanisms, and immunomodulatory functions is expected to enhance targeting specificity and therapeutic efficacy. In addition, improving biological barrier penetration and intracellular delivery remains critical, particularly for macromolecular therapeutics. Simplified, scalable designs with well-defined structures will be essential for clinical translation. Overall, acid-responsive drug delivery systems are transitioning toward intelligent, microenvironment-adaptive systems, offering significant potential for next-generation precision medicine.",
  "abstract_shown": true,
  "affiliations": [
    "School of Biomedical Engineering, Guangzhou Medical University, Guangzhou 510260, China.",
    "Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.",
    "Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing 100871, China.",
    "Beijing Advanced Center of RNA Biology (BEACON), Peking University, Beijing 100871, China.",
    "Department of General Surgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230026, China.",
    "College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Haiping Zhong"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yan Zong",
      "orcid": "0000-0002-9167-1859"
    },
    {
      "affs": [
        4
      ],
      "name": "Haoyu Du"
    },
    {
      "affs": [
        4
      ],
      "name": "Jingzhi Wang"
    },
    {
      "affs": [
        5
      ],
      "name": "Shuang Qu"
    },
    {
      "affs": [
        4
      ],
      "name": "Ningqiang Gong",
      "orcid": "0000-0002-9444-8505"
    },
    {
      "affs": [
        5
      ],
      "name": "Bingran Yu",
      "orcid": "0000-0003-4912-5632"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Qiang Cheng",
      "orcid": "0000-0002-5213-5084"
    },
    {
      "affs": [
        1
      ],
      "name": "Shutao Guo",
      "orcid": "0000-0002-0916-7451"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/60qgc60s41jdt.bib",
  "cited_by": 4,
  "doi": "10.1021/polymscitech.6c00051",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718360/?tool=EBI",
  "id": "60qgc60s41jdt",
  "issns": [
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  "landing_url": "https://europepmc.org/article/PMC/PMC13718360",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
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  "openalex": "W7164904959",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718360/pdf/?tool=EBI",
  "pmcid": "PMC13718360",
  "pmid": "42959787",
  "published": "2026-06-16",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/60qgc60s41jdt.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13718360",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13718360"
    },
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42959787",
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      "url": "https://europepmc.org/article/MED/42959787"
    },
    {
      "first_seen": "2026-11-02T12:22:24Z",
      "native_id": "PMC13718360",
      "source": "pmc",
      "url": "https://doi.org/10.1021/polymscitech.6c00051"
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Acid-Responsive Drug Delivery Systems: Advances and Perspectives",
  "title_text": "Acid-Responsive Drug Delivery Systems: Advances and Perspectives",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:24Z",
  "url": "https://research.draconitic.com/paper/60qgc60s41jdt",
  "venue": "Polymer science & technology (Washington, D.C.)",
  "versions": []
}