{
  "abstract": "Photoenolization/Diels-Alder (PEDA) reactions provide a rapid approach to highly substituted 1-tetralols. Herein, we report a PEDA strategy using activated acrylate-based dienophiles for the synthesis of densely functionalized 1-tetralols with high diastereoselectivity. Isatin-derived acrylates enable access to spirocyclic architectures, while chiral auxiliary-based acrylates allow an asymmetric variant, providing enantioenriched 1-tetralol derivatives with efficient stereocontrol.",
  "abstract_shown": true,
  "affiliations": [
    "Departamento de Química Orgánica/Institute of Organic Synthesis and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Alicante, 03080-Alicante, Spain."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "María González-Marcos"
    },
    {
      "affs": [
        0
      ],
      "name": "José Trujillo-Sierra"
    },
    {
      "affs": [
        0
      ],
      "name": "Enara Esteban"
    },
    {
      "affs": [
        0
      ],
      "name": "José M Sansano",
      "orcid": "0000-0002-5536-2717"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana Sirvent",
      "orcid": "0000-0001-6127-4011"
    },
    {
      "affs": [
        0
      ],
      "name": "María de Gracia Retamosa",
      "orcid": "0000-0003-1131-5916"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/612hfy5jk997x.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.6c03349",
  "fulltext_url": "https://europepmc.org/articles/PMC13595907",
  "id": "612hfy5jk997x",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://europepmc.org/article/MED/42918043",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Asymmetric Synthesis and Catalysis"
    ]
  ],
  "openalex": "W7207849779",
  "pdf_url": "https://europepmc.org/articles/PMC13595907?pdf=render",
  "pmcid": "PMC13595907",
  "pmid": "42918043",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/612hfy5jk997x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42918043",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42918043"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Asymmetric Synthesis and Catalysis",
      "subfield": "organic"
    }
  ],
  "title": "Asymmetric Access to Structurally Complex 1-Tetralols through Diels-Alder Cycloadditions of Photogenerated Hydroxy-o-quinodimethanes and Acrylates.",
  "title_text": "Asymmetric Access to Structurally Complex 1-Tetralols through Diels-Alder Cycloadditions of Photogenerated Hydroxy-o-quinodimethanes and Acrylates.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/612hfy5jk997x",
  "venue": "Organic letters",
  "versions": []
}