{
  "abstract": "Background: PET-CT (Positron emission tomography–computed tomography), a nuclear medicine imaging technique is preferably used for lung tumor detection. However, manual image analysis may be time-consuming. To enhance efficiency, many automated segmentation algorithms have been developed. This study aims to develop a radiomics agreement-based method to evaluate segmentation algorithms and to compare the performance of two deep learning-based algorithms nnU-Net (No-new-net Convolutional Neural Network) and RECOMIA (Research Consortium for Medical Image Analysis Lung Cancer “Lung Cancer FDG-PET/CT v1.5”) for PET-CT solitary lung tumor segmentation. Methods and results: PET-CT images of 221 patients at the University of Debrecen’s Hospital were collected and anonymized. The predictions of segmented lung tumors done by nnU-Net and RECOMIA were compared with the manual segmented masks via Wilcoxon signed-rank test and Pearson correlation values, based on eight groups of radiomics parameters calculated by PyRadiomics software. The combined p-values were calculated using Brown’s method, which were 0.481 and < 0.001 for nnU-Net and RECOMIA, respectively. The absolute values of correlation were summed, which were 37.259 and 16.358 for nnU-Net and RECOMIA, respectively. Altogether, RECOMIA shows statistically greater differences, therefore, it performs worse than nnU-Net does. Statistical analyses with Intraclass correlation coefficients (ICC), Multivariate analysis of variance (MANOVA) and follow up pairwise t-test further confirmed stronger agreement between extracted radiomics features from nnU-Net predicted masks and manual masks than RECOMIA and manual masks, which validated the proposed comparison method. Conclusion: The superior performance of nnU-Net highlights the importance of training data alignment and model adaptability in achieving accurate and reliable segmentation in medical imaging. However, nnU-Net requirements for training and extra computational demands may limit its application in some clinical environments. Despite lower accuracy, RECOMIA remains valuable because of its efficiency and intuitiveness. These findings provide valuable guidance for selecting segmentation algorithms in real-world clinical and research settings.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Debrecen, Hungary",
    "Scanomed Ltd., Debrecen, Hungary"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Duc Trung Le"
    },
    {
      "affs": [
        1
      ],
      "name": "Dániel Szabó"
    },
    {
      "name": "Sándor Aranyi"
    },
    {
      "name": "Márton Mikó"
    },
    {
      "name": "Zita Képes"
    },
    {
      "name": "Iván Mihovk"
    },
    {
      "name": "Anna Rebeka Kovács"
    },
    {
      "name": "Iván Gábor Nagy"
    },
    {
      "name": "Bence Farkas"
    },
    {
      "name": "István Hajdú"
    },
    {
      "name": "György Trencsényi"
    },
    {
      "name": "Lajos Trón"
    },
    {
      "name": "Miklós Emri"
    },
    {
      "name": "Gábor Opposits"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6136nefe42xrf.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0360849",
  "fulltext_url": null,
  "id": "6136nefe42xrf",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0360849",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "plos",
      "/Biology and life sciences/Neuroscience/Neuroimaging"
    ],
    [
      "plos",
      "/Biology and life sciences/Neuroscience/Neuroimaging/Positron emission tomography"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/Diagnostic radiology/Pulmonary imaging"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/Diagnostic radiology/Tomography/Positron emission tomography"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Lung and intrathoracic tumors"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Lung and intrathoracic tumors/Secondary lung tumors"
    ],
    [
      "plos",
      "/Medicine and health sciences/Radiology and imaging/Diagnostic radiology/Pulmonary imaging"
    ],
    [
      "plos",
      "/Medicine and health sciences/Radiology and imaging/Diagnostic radiology/Tomography/Positron emission tomography"
    ],
    [
      "plos",
      "/Physical sciences/Mathematics/Applied mathematics/Algorithms"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques/Diagnostic radiology/Pulmonary imaging"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques/Diagnostic radiology/Tomography/Positron emission tomography"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques/Neuroimaging"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques/Neuroimaging/Positron emission tomography"
    ],
    [
      "plos",
      "/Research and analysis methods/Simulation and modeling/Algorithms"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/6136nefe42xrf.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:20:42Z",
      "native_id": "10.1371/journal.pone.0360849",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0360849"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:diagnostic radiology",
      "subfield": "imaging"
    },
    {
      "field": "medicine",
      "origin": "plos:cancers and neoplasms",
      "subfield": "oncology"
    }
  ],
  "title": "Assessment of algorithmic performance in PET-CT segmentation of solitary lung tumors",
  "title_text": "Assessment of algorithmic performance in PET-CT segmentation of solitary lung tumors",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:24Z",
  "url": "https://research.draconitic.com/paper/6136nefe42xrf",
  "venue": "PLOS One",
  "versions": []
}