{
  "abstract": "Tauopathies are pathologies wherein phosphorylated insoluble tau aggregates in neurons, leading to dysfunction and degeneration. Positron emission tomography (PET) enables measurement of in vivo tau, with second-generation radiotracers such as [18F]MK6240 showing high tau affinity with minimal off-target binding. While tauopathies are commonly linked to age-related neurodegenerative diseases, notably Alzheimer’s disease (AD), evidence suggests pathophysiological cascades may begin long before clinical onset. Increasingly, tau is recognized in pathologies affecting younger individuals, including autosomal dominant AD, Niemann-Pick disease type C, chronic traumatic encephalopathy, and epilepsy, thus highlighting the importance of normative data in non-geriatric populations. Here, we present a dataset of 33 young to middle-age healthy adults (mean age 34.0 ± 10.4 years, 12 female) with [18F]MK6240 PET data and T1w magnetic resonance imaging. Longitudinal data are also available in a subset of 9 participants with a minimum follow-up time of 1 year. Our dataset aims to support imaging biomarker studies on younger individuals potentially at risk for AD and to advance work in tauopathies affecting non-geriatric populations generally excluded from neurodegeneration studies.",
  "abstract_shown": true,
  "affiliations": [
    "Multimodal Imaging and Connectome Analysis (MICA) Laboratory and Centre of Excellence in Epilepsy at the Neuro (CEEN), Montréal Neurological Institute and Hospital, McGill University, Montréal, Québec Canada",
    "Montréal Neurological Institute, McGill University Health Centre, Montréal, Québec Canada",
    "McConnell Brain Imaging Centre, Montréal Neurological Institute and Hospital, McGill University, Montréal, Québec Canada",
    "Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Montréal, Québec Canada",
    "Peter O’Donnell Jr. Brain Institute (OBI), University of Texas Southwestern Medical Centre (UTSW), Dallas, Texas USA",
    "Douglas Mental Health University Institute, McGill University, Montréal, Québec Canada",
    "Queen Square Institute of Neurology, University College London, London, United Kingdom",
    "Department of Neurology, Inselspital, Sleep-Wake-Epilepsy Center, Bern University Hospital, University of Bern, Bern, Switzerland"
  ],
  "article_type": "data paper",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jack Lam",
      "orcid": "0000-0003-3173-7665"
    },
    {
      "affs": [
        0
      ],
      "name": "Raúl Rodriguez-Cruces",
      "orcid": "0000-0002-2917-1212"
    },
    {
      "affs": [
        0
      ],
      "name": "Thaera Arafat"
    },
    {
      "affs": [
        0
      ],
      "name": "Jessica Royer",
      "orcid": "0000-0002-4448-8998"
    },
    {
      "affs": [
        0
      ],
      "name": "Judy Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Arielle Dascal"
    },
    {
      "affs": [
        0
      ],
      "name": "Ella Sahlas"
    },
    {
      "affs": [
        1
      ],
      "name": "Raluca Pana"
    },
    {
      "affs": [
        2
      ],
      "name": "Robert Hopewell"
    },
    {
      "affs": [
        2
      ],
      "name": "Chris Hung-Hsin Hsiao"
    },
    {
      "affs": [
        2
      ],
      "name": "Gassan Massarweh"
    },
    {
      "affs": [
        2
      ],
      "name": "Jean-Paul Soucy"
    },
    {
      "affs": [
        1,
        2,
        3,
        4
      ],
      "name": "Pedro Rosa-Neto",
      "orcid": "0000-0001-9116-1376"
    },
    {
      "affs": [
        5
      ],
      "name": "Sylvia Villeneuve"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Lorenzo Caciagli"
    },
    {
      "affs": [
        6
      ],
      "name": "Matthias Koepp"
    },
    {
      "affs": [
        1
      ],
      "name": "Andrea Bernasconi"
    },
    {
      "affs": [
        1
      ],
      "name": "Neda Bernasconi"
    },
    {
      "affs": [
        0
      ],
      "name": "Boris Bernhardt"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6151k0mf6h1h7.bib",
  "cited_by": 0,
  "doi": "10.1038/s41597-026-07656-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13713985/",
  "id": "6151k0mf6h1h7",
  "issns": [
    "2052-4463"
  ],
  "landing_url": "https://doi.org/10.1038/s41597-026-07656-8",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Data Descriptor"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7167348102",
  "pdf_url": "https://www.nature.com/articles/s41597-026-07656-8_reference.pdf",
  "pmcid": "PMC13713985",
  "pmid": "42401601",
  "published": "2026-07-04",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/6151k0mf6h1h7.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:34Z",
      "native_id": "PMC13713985",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41597-026-07656-8"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "An open dataset of cerebral tau deposition in young healthy adults based on [18F]MK6240 positron emission tomography",
  "title_text": "An open dataset of cerebral tau deposition in young healthy adults based on [18F]MK6240 positron emission tomography",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:34Z",
  "url": "https://research.draconitic.com/paper/6151k0mf6h1h7",
  "venue": "Scientific Data",
  "versions": []
}