{
  "abstract": "Methionine 1-linked ubiquitin (Met1-Ub) is a non-degradative protein modification that is generated solely by the Linear Ub Chain Assembly Complex (LUBAC) and hydrolysed by the deubiquitinases OTULIN and CYLD. The Met1-Ub system has emerged as a critical regulator of immune receptor signalling, specially known for activating NF-κB downstream of the TNF receptor superfamily. Studies from human patients and mouse models have shown that the Met1-Ub system is also critical for the development, maintenance, and function of T cells. However, manipulation of the Met1-Ub system in T cells has yielded discrepant results, and the molecular underpinnings underlying the regulation of T cells by the Met1-Ub system remain unclear. This mini-review summarises the current consensus and highlights the unresolved questions surrounding the role of the Met1-Ub system in T cells.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Immunology and Microbiology, LEO Foundation Skin Immunology Research Center, University of Copenhagen, Copenhagen, Denmark."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "John Rizk",
      "orcid": "0000-0002-3352-5474"
    },
    {
      "affs": [
        0
      ],
      "name": "Mads Gyrd-Hansen",
      "orcid": "0000-0001-5641-5019"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/620thxssryejb.bib",
  "cited_by": 0,
  "doi": "10.1111/sji.70155",
  "fulltext_url": "https://europepmc.org/articles/PMC13687778",
  "id": "620thxssryejb",
  "issns": [
    "0300-9475",
    "1365-3083"
  ],
  "landing_url": "https://europepmc.org/article/MED/42908223",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|NF-κB Signaling Pathways"
    ]
  ],
  "openalex": "W7223185743",
  "pdf_url": "https://europepmc.org/articles/PMC13687778?pdf=render",
  "pmcid": "PMC13687778",
  "pmid": "42908223",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/620thxssryejb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42908223",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42908223"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|NF-κB Signaling Pathways",
      "subfield": "oncology"
    }
  ],
  "title": "The Met1-Ub System in T Cells: What We Know, What We Think We Know.",
  "title_text": "The Met1-Ub System in T Cells: What We Know, What We Think We Know.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/620thxssryejb",
  "venue": "Scandinavian journal of immunology",
  "versions": []
}