{
  "abstract": "Objectives: To investigate the diagnostic and prognostic value and immune-related associations of LRRC8C, a volume-regulated anion channel (VRAC) subunit, in lower-grade glioma (LGG).\n\nBackground: LGG often progresses to high-grade malignancy, complicating diagnosis and treatment. LRRC8C, a VRAC subunit, influences immune regulation in various cancers, but its role in LGG remains uncharacterized.\n\nMethods: Using uniformly reprocessed transcriptomic and clinical data from the TCGA-LGG and GTEx cohorts (UCSC Xena Toil dataset), we performed differential expression, survival, gene set enrichment (GSEA), and immune infiltration analyses of LRRC8C in LGG.\n\nResults: LRRC8C was significantly upregulated in LGG tissues with potential diagnostic value (AUC = 0.821, 95% CI: 0.801–0.842). Higher LRRC8C expression was associated with shorter overall survival (OS) and progression-free interval (PFI); this association was attenuated after adjustment for age and IDH status (multivariate Cox P = 0.054), indicating that LRRC8C overlaps with—rather than acts independently of—established molecular factors. This pattern was externally validated in the Chinese Glioma Genome Atlas (CGGA) cohort (n = 271). GSEA showed enrichment in immune and vascular pathways. Cross-validation with seven deconvolution algorithms confirmed robust positive correlations between LRRC8C expression and infiltration of CD8+ T cells, B cells, neutrophils, and dendritic cells, whereas the natural killer (NK) cell association was not robust. These findings are correlative and require experimental confirmation.\n\nConclusion: LRRC8C is a potential diagnostic biomarker and prognostic indicator in LGG, although its prognostic value is not fully independent of established molecular factors. Its immune-related associations are hypothesis-generating and require experimental verification.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China",
    "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Supportive Care Department, Peking University Cancer Hospital & Institute, Beijing, China",
    "Department of Neurosurgery, The Sixth Medical Center of PLA General Hospital, Beijing, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Leiming Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yujie Mu"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenying Lv"
    },
    {
      "affs": [
        2
      ],
      "name": "Mei Cui"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianning Zhang",
      "orcid": "0009-0002-9339-5736"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/623wv4fhmcw12.bib",
  "cited_by": 0,
  "doi": "10.1177/20503121261488327",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724862/",
  "id": "623wv4fhmcw12",
  "issns": [
    "2050-3121"
  ],
  "landing_url": "https://doi.org/10.1177/20503121261488327",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research Article"
    ],
    [
      "openalex",
      "2716|Glioma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7213276176",
  "pdf_url": "https://europepmc.org/articles/PMC13724862?pdf=render",
  "pmcid": "PMC13724862",
  "pmid": "42973957",
  "published": "2026-09-16",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/623wv4fhmcw12.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:21Z",
      "native_id": "PMC13724862",
      "source": "pmc",
      "url": "https://doi.org/10.1177/20503121261488327"
    },
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42973957",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973957"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Glioma Diagnosis and Treatment",
      "subfield": "human-genetics"
    }
  ],
  "title": "LRRC8C is a potential diagnostic and prognostic biomarker associated with immune modulation in lower-grade glioma",
  "title_text": "LRRC8C is a potential diagnostic and prognostic biomarker associated with immune modulation in lower-grade glioma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:15Z",
  "url": "https://research.draconitic.com/paper/623wv4fhmcw12",
  "venue": "SAGE Open Medicine",
  "versions": []
}