{
  "abstract": "Chromatin mobility, the exploration of 3D conformations by the chromatin fibre, is implicated in transcription and DNA repair, and is thought to decrease progressively as cells differentiate. Here, combining live-cell 3D single-nucleosome tracking with genomic approaches, we show that chromatin mobility instead changes in a cell-type-specific manner, increasing as pluripotent cells acquire posterior fates. This is accompanied by 3D genome reorganisation, including loss of Polycomb-associated interactions and emergence of CDX2-associated interactions. Withdrawal of posteriorising WNT/{beta}-catenin signalling rapidly reduces chromatin mobility and partially restores Polycomb-associated chromatin interactions, while Cdx1/2/4-null cells fail to acquire these WNT/{beta}-catenin-dependent changes. Together, our findings establish chromatin mobility as a regulated property of cell state, with WNT/{beta}-catenin signalling and CDX factors acting as mediators that fine-tune the sampling of 3D chromatin interactions during cell state transitions.",
  "abstract_shown": true,
  "affiliations": [
    "Imperial College London"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "A. A. M. Wurmser"
    },
    {
      "name": "L. Mao"
    },
    {
      "name": "N. Markevych"
    },
    {
      "name": "G. G. Agsu"
    },
    {
      "name": "Y. Cao"
    },
    {
      "name": "Z. Zhang"
    },
    {
      "name": "M. Jonaitis"
    },
    {
      "name": "N. De Winter"
    },
    {
      "name": "B. D. Simons"
    },
    {
      "name": "P. M. Madapura"
    },
    {
      "name": "D. Holcman"
    },
    {
      "name": "T. E. Boroviak"
    },
    {
      "name": "D. Klenerman"
    },
    {
      "name": "S. Samarajiwa"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Basu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/62acpa8w76gha.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.05.756771",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756771v1.full",
  "id": "62acpa8w76gha",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756771v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cell biology"
    ],
    [
      "openalex",
      "1312|Genomics and Chromatin Dynamics"
    ]
  ],
  "openalex": "W7220675536",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756771v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/62acpa8w76gha.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:12Z",
      "native_id": "10.64898/2026.10.05.756771",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756771v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "WNT/β-catenin increases 3D chromatin mobility and reorganisation during posterior cell state transitions",
  "title_text": "WNT/β-catenin increases 3D chromatin mobility and reorganisation during posterior cell state transitions",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:12Z",
  "url": "https://research.draconitic.com/paper/62acpa8w76gha",
  "venue": "bioRxiv",
  "versions": []
}