{
  "abstract": "Background: Real‐world data on benralizumab in patients with severe eosinophilic asthma–while controlling for confounding factors–is currently lacking.\n\nAim: This real‐world controlled multicentre study evaluated asthma outcomes in patients who received benralizumab compared with a severe asthma cohort who did not receive biologic therapy.\n\nMethods: Two years of data from patients with severe eosinophilic asthma in the Australian Benralizumab Registry (ABenRa) and the Australasian Severe Asthma Registry (ASAR) were included in the analysis. Asthma control questionnaire‐5 (ACQ‐5) scores, asthma‐related quality of life (AQLQ) scores, maintenance oral corticosteroid (OCS) dose, annualised exacerbation rate and clinical remission (ACQ‐5 ≤ 1, with no asthma attacks or OCS use for 12 months, assessed at the 24‐month follow‐up) rates were compared between the groups after adjusting for baseline imbalances.\n\nResults: A total of 211 participants from ABenRa (64.5% female; mean age 57.4 ± 14.5 years) and 250 from ASAR (63.1% female; mean age 53.7 ± 14.8 years) were included. ACQ and AQLQ improved significantly in both groups. Participants in the ABenRa showed greater improvements in ACQ at 12‐ (β = −0.5, p = 0.002) and 24‐months (β = −0.5, p = 0.003), as well as in AQLQ at 12‐ (β = 0.6, p < 0.001) and 24‐months (β = 0.4, p = 0.019), compared with the ASAR group, with no difference in maintenance OCS dose or annualised exacerbation rates between groups. At 12‐ and 24‐months, approximately 60% of participants in the ABenRa achieved controlled or partially controlled asthma as per the GINA guidelines. Notably, clinical benefit was evident within 14 days of initiating treatment. A higher proportion of participants in the ABenRa achieved clinical remission (30.9% vs. 20.4%; OR 2.1 (95% CI 1.1, 4.1), p = 0.037).\n\nConclusion: Benralizumab was associated with significant improvement in asthma outcomes in patients with severe eosinophilic asthma. This benefit persisted when compared with patients who had severe eosinophilic asthma but did not receive any biologic therapy.",
  "abstract_shown": true,
  "affiliations": [
    "College of Health, Medicine and Wellbeing University of Newcastle Callaghan New South Wales Australia",
    "Centre of Excellence in Treatable Traits, Hunter Medical Research Institute, Asthma and Breathing Programme Newcastle New South Wales Australia",
    "Department of Respiratory and Sleep Medicine John Hunter Hospital Newcastle New South Wales Australia",
    "Department of Respiratory and Sleep Medicine Austin Health Melbourne Victoria Australia",
    "Department of Respiratory Medicine Fiona Stanley Hospital Murdoch Western Australia Australia",
    "Department of Thoracic Medicine Concord Hospital Concord Australia",
    "Macquarie Medical School, Faculty of Medicine, Health and Human Sciences Macquarie University Sydney New South Wales Australia",
    "Graduate School of Health University of Technology Sydney Sydney New South Wales Australia",
    "Clinical Research Centre for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Japan",
    "School of Medicine and Public Health University of Newcastle Newcastle New South Wales Australia",
    "The Thoracic Society of Australia and New Zealand Sydney New South Wales Australia",
    "Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia",
    "Allergy, Asthma and Clinical Immunology Alfred Health Melbourne Victoria Australia",
    "School of Medicine Western Sydney University Campbelltown New South Wales Australia",
    "Immunology and Allergy Unit Campbelltown Hospital Campbelltown New South Wales Australia",
    "Woolcock Institute of Medical Research University of Sydney Glebe New South Wales Australia",
    "The University of Notre Dame Sydney Western Australia Australia",
    "St George Specialist Centre Kogarah New South Wales Australia",
    "St Vincent's Clinic Darlinghurst New South Wales Australia",
    "Faculty of Medicine, Nursing and Health Sciences Monash University Clayton Victoria Australia",
    "Department of Thoracic Medicine Frankston Hospital Frankston Victoria Australia",
    "Department of Respiratory and Sleep Medicine Westmead Hospital Sydney New South Wales Australia",
    "Ludwig Engel Centre for Respiratory Research The Westmead Institute of Medical Research Sydney New South Wales Australia",
    "Westmead Clinical School University of Sydney Sydney New South Wales Australia",
    "Lung Research University of Adelaide and Department of Thoracic Medicine, Royal Adelaide Hospital Adelaide Australia",
    "Rhinology and Skull Base Research Group, Applied Medical Research Centre University of New South Wales Sydney Australia",
    "Faculty of Medicine Notre Dame University Sydney Australia",
    "Eastern Health and Monash University Melbourne Victoria Australia",
    "Thoracic and Sleep Medicine Cairns and Hinterland Hospital and Health Service Cairns Queensland Australia",
    "Faculty of Medicine The University of Queensland Brisbane Queensland Australia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Dennis Thomas"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Vanessa M. McDonald"
    },
    {
      "affs": [
        0
      ],
      "name": "Gijo Thomas"
    },
    {
      "affs": [
        3
      ],
      "name": "Joy Lee",
      "orcid": "0000-0002-9881-9895"
    },
    {
      "affs": [
        4
      ],
      "name": "Li Ping Chung"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Matthew Peters"
    },
    {
      "affs": [
        7
      ],
      "name": "Shakti D. Shukla"
    },
    {
      "affs": [
        0,
        1,
        8
      ],
      "name": "Yuto Hamada"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Erin S. Harvey",
      "orcid": "0000-0002-7647-8858"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Michael Fricker"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Hayley See"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rejoy Sabin Thomas",
      "orcid": "0009-0001-0911-6953"
    },
    {
      "affs": [
        5,
        6,
        11
      ],
      "name": "Claude S. Farah",
      "orcid": "0000-0003-2489-227X"
    },
    {
      "affs": [
        12
      ],
      "name": "Andrew Gillman"
    },
    {
      "affs": [
        13,
        14
      ],
      "name": "Constance H. Katelaris"
    },
    {
      "affs": [
        15,
        16,
        17,
        18
      ],
      "name": "Gregory P. Katsoulotos"
    },
    {
      "affs": [
        19,
        20
      ],
      "name": "David Langton"
    },
    {
      "affs": [
        21,
        22,
        23
      ],
      "name": "Peter G. Middleton",
      "orcid": "0000-0003-3361-4941"
    },
    {
      "affs": [
        24
      ],
      "name": "Paul Reynolds"
    },
    {
      "affs": [
        25,
        26
      ],
      "name": "Janet Rimmer"
    },
    {
      "affs": [
        27
      ],
      "name": "Francis Thien"
    },
    {
      "affs": [
        28
      ],
      "name": "Stephen Vincent"
    },
    {
      "affs": [
        29
      ],
      "name": "John W. Upham"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Peter G. Gibson"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/62gbazemnjc2p.bib",
  "cited_by": 1,
  "doi": "10.1111/cea.70348",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13727326/",
  "id": "62gbazemnjc2p",
  "issns": [
    "0954-7894",
    "1365-2222"
  ],
  "landing_url": "https://doi.org/10.1111/cea.70348",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2737|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7162571353",
  "pdf_url": null,
  "pmcid": "PMC13727326",
  "pmid": "42200301",
  "published": "2026-05-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/62gbazemnjc2p.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:23:25Z",
      "native_id": "PMC13727326",
      "source": "pmc",
      "url": "https://doi.org/10.1111/cea.70348"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Asthma and respiratory diseases",
      "subfield": "physiology"
    }
  ],
  "title": "A Real‐World Controlled Multicentre Study Evaluating the Association Between Benralizumab Therapy and Major Outcomes in Severe Asthma",
  "title_text": "A Real‐World Controlled Multicentre Study Evaluating the Association Between Benralizumab Therapy and Major Outcomes in Severe Asthma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:23:01Z",
  "url": "https://research.draconitic.com/paper/62gbazemnjc2p",
  "venue": "Clinical and Experimental Allergy",
  "versions": []
}